Results 21 to 30 of about 338,804 (265)

Structural variant evolution after telomere crisis

Nature Communications, 2021
Telomere crisis has been shown to induce chromothripsis and breakage fusion bridge (BFB) cycles in vitro. Here, the authors show that telomere crisis generates a much broader spectrum of structural variations, implying that cancers without chromothripsis
Sally M. Dewhurst, Xiaotong Yao, Joel Rosiene, Huasong Tian, Julie Behr, Nazario Bosco, Kaori K. Takai, Titia de Lange, Marcin Imieliński   +8 more
doaj   +1 more source

SARS-CoV CH.1.1 Variant: Genomic and Structural Insight

Infectious Disease Reports, 2023
In early February 2023, the Omicron subvariant XBB.1.5, also known as “Kraken”, accounted for more than 44% of new COVID-19 cases worldwide, whereas a relatively new Omicron subvariant named CH.1.1, deemed “Orthrus”, accounted for less than 6% of new ...
Liliana Bazzani, Elena Imperia, Fabio Scarpa, Daria Sanna, Marco Casu, Alessandra Borsetti, Stefano Pascarella, Nicola Petrosillo, Eleonora Cella, Marta Giovanetti, Massimo Ciccozzi   +10 more
doaj   +1 more source

Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication

BMC Genomics, 2020
Background Advances in genome technology have simplified a new comprehension of the genetic and historical processes crucial to rapid phenotypic evolution under domestication. To get new insight into the genetic basis of the dog domestication process, we
Zeinab Amiri Ghanatsaman, Guo-Dong Wang, Hojjat Asadollahpour Nanaei, Masood Asadi Fozi, Min-Sheng Peng, Ali Esmailizadeh, Ya-Ping Zhang   +6 more
doaj   +1 more source

Spatially variant periodic structures in electromagnetics [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2015
Spatial transforms are a popular technique for designing periodic structures that are macroscopically inhomogeneous. The structures are often required to be anisotropic, provide a magnetic response, and to have extreme values for the constitutive parameters in Maxwell's equations.
Rumpf, Raymond C., Pazos, Javier J., Digaum, Jennefir L., Kuebler, Stephen M.   +3 more
openaire   +3 more sources

Mutacin 1140 Lantibiotic Variants Are Efficacious Against Clostridium difficile Infection

Frontiers in Microbiology, 2018
Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including Clostridium difficile.
Johan A. Kers, Robert E. Sharp, Anthony W. Defusco, Jae H. Park, Jin Xu, Mark E. Pulse, William J. Weiss, Martin Handfield   +7 more
doaj   +1 more source

Detection and evaluation of copy number variation using both linked-read and short-read sequencing in New Zealand dairy cattle

Frontiers in Genetics
In recent years, genetic studies have made significant progress in identifying single-nucleotide polymorphisms (SNPs) associated with cattle health and production traits. However, it is still challenging to identify and validate more complicated forms of
Yu Wang, Tony Nugroho, Thomas J. J. Johnson, Christine Couldrey, Bevin L. Harris   +4 more
doaj   +1 more source

Hidden biases in germline structural variant detection

Genome Biology, 2021
Background Genomic structural variations (SV) are important determinants of genotypic and phenotypic changes in many organisms. However, the detection of SV from next-generation sequencing data remains challenging.
Michael M. Khayat, Sayed Mohammad Ebrahim Sahraeian, Samantha Zarate, Andrew Carroll, Huixiao Hong, Bohu Pan, Leming Shi, Richard A. Gibbs, Marghoob Mohiyuddin, Yuanting Zheng, Fritz J. Sedlazeck   +10 more
doaj   +1 more source

Structure and stability of the P93G variant of ribonuclease A [PDF]

Protein Science, 1998
AbstractThe peptide bonds preceding Pro 93 and Pro 114 of bovine pancreatic ribonuclease A (RNase A) are in the cis conformation. The trans‐to‐cis isomerization of these bonds had been indicted as the slow step during protein folding. Here, site‐directed mutagenesis was used to replace Pro 93 or Pro 114 with a glycine residue, and the crystalline ...
L W, Schultz, S R, Hargraves, T A, Klink, R T, Raines   +3 more
openaire   +2 more sources

Structural variants in 3000 rice genomes [PDF]

Genome Research, 2019
Investigation of large structural variants (SVs) is a challenging yet important task in understanding trait differences in highly repetitive genomes. Combining different bioinformatic approaches for SV detection, we analyzed whole-genome sequencing data from 3000 rice genomes and identified 63 million individual SV calls that grouped into 1.5 million ...
Roven Rommel Fuentes, Dmytro Chebotarov, Jorge Duitama, Sean Smith, Juan Fernando De la Hoz, Marghoob Mohiyuddin, Rod A. Wing, Kenneth L. McNally, Tatiana Tatarinova, Andrey Grigoriev, Ramil Mauleon, Nickolai Alexandrov   +11 more
openaire   +6 more sources

TRPV1 splice variants: structure and function [PDF]

Frontiers in Bioscience, 2010
The capsaicin receptor (TRPV1) is a non-selective cation channel predominantly expressed in specialized sensory neurons that detect painful stimuli. Although its many functional roles continue to be revealed, it has been confirmed to play a critical role in the perception of peripheral inflammatory hyperalgesia and pain.
Mark A, Schumacher, Helge, Eilers
openaire   +2 more sources