Results 31 to 40 of about 864,768 (299)

Mutacin 1140 Lantibiotic Variants Are Efficacious Against Clostridium difficile Infection

Frontiers in Microbiology, 2018
Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including Clostridium difficile.
Johan A. Kers, Robert E. Sharp, Anthony W. Defusco, Jae H. Park, Jin Xu, Mark E. Pulse, William J. Weiss, Martin Handfield   +7 more
doaj   +1 more source

An integrated map of structural variation in 2,504 human genomes [PDF]

, 2015
Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classes comprising both balanced and unbalanced variants, which we
Abyzov, A., Alkan, C., Antaki, D., Auton, A., Bae, T., Bashir, A., Batzer, M.A., Casale F.P., Cerveira, E., Chaisson, M.J.P., Chen J., Chen, K., Chines P., Chong, Z., Clarke L., Dal, E., Dayama G., Devine, S.E., Ding L., Eichler, E.E., Emery, S., Fan X., Flicek P., Fritz, M.H.-Y., Gardner, E.J., Garrison, E., Gerstein, M.B., Gibbs, R.A., Gujral, M., Handsaker, R.E., Hormozdiari F., Huddleston J., Jun G., Kahveci F., Kashin, S., Kidd J.M., Kong, Y., Konkel, M.K., Korbel J.O., Lam H.Y.K., Lameijer, E.-W., Lee, C., Malhotra, A., Malig, M., Marth G., Mason, C.E., McCarroll, S.A., McCarthy, S., Meiers, S., Menelaou, A., Mills, R.E., Mu X.J., Muzny, D.M., Nelson, B.J., Noor, A., Parrish, N.F., Pendleton, M., Quitadamo, A., Raeder, B., Rausch, T., Romanovitch, M., Schadt, E.E., Schlattl, A., Sebat J., Sebra, R., Shabalin, A.A., Shi X., Stegle O., Stütz, A.M., Sudmant P.H., Untergasser, A., Walker J.A., Walter, K., Wang, M., Ye, K., Yu F., Zhang J., Zhang, C., Zhang, Y., Zheng-Bradley X., Zhou W., Zichner, T.   +81 more
core   +1 more source

TRPV1 splice variants: structure and function [PDF]

Frontiers in Bioscience, 2010
The capsaicin receptor (TRPV1) is a non-selective cation channel predominantly expressed in specialized sensory neurons that detect painful stimuli. Although its many functional roles continue to be revealed, it has been confirmed to play a critical role in the perception of peripheral inflammatory hyperalgesia and pain.
Mark A, Schumacher, Helge, Eilers
openaire   +2 more sources

Hidden biases in germline structural variant detection

Genome Biology, 2021
Background Genomic structural variations (SV) are important determinants of genotypic and phenotypic changes in many organisms. However, the detection of SV from next-generation sequencing data remains challenging.
Michael M. Khayat, Sayed Mohammad Ebrahim Sahraeian, Samantha Zarate, Andrew Carroll, Huixiao Hong, Bohu Pan, Leming Shi, Richard A. Gibbs, Marghoob Mohiyuddin, Yuanting Zheng, Fritz J. Sedlazeck   +10 more
doaj   +1 more source

Resolution of Key Roles for the Distal Pocket Histidine in Cytochrome c Nitrite Reductases [PDF]

, 2015
Cytochrome c nitrite reductases perform a key step in the biogeochemical N-cycle by catalyzing the six-electron reduction of nitrite to ammonium. These multi-heme cytochromes contain a number of His/His ligated c-hemes for electron transfer and a ...
Burlat, Benedicte, Butt, Julea, Cheesman, Myles, Clarke, Tom, Kern, Melanie, Lockwood, Colin, Richardson, David, Simon, Jorg   +7 more
core   +5 more sources

SVIM: Structural Variant Identification using Mapped Long Reads

, 2019
Motivation: Structural variants are defined as genomic variants larger than 50bp. They have been shown to affect more bases in any given genome than SNPs or small indels. Additionally, they have great impact on human phenotype and diversity and have been
Heller, D., Vingron, M.
core   +1 more source

Dissociation of structural and functional integrities of the motor system in amyotrophic lateral sclerosis and behavioral-variant frontotemporal dementia [PDF]

, 2016
Background and Purpose: This study investigated the structural and functional changes in the motor system in amyotrophic lateral sclerosis (ALS; n=25) and behavioral-variant fronto-temporal dementia (bvFTD; n=17) relative to healthy controls (n=37 ...
Bae, Jong Seok, Burrell, James, Ferguson, Michele, Hodges, John R., Hornberger, Michael, Kiernan, Matthew C., Mioshi, Eneida, Simon, Neil, Tan, Rachel, Vucic, Steve   +9 more
core   +2 more sources

Structural Characterization of Histone H2A Variants [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2004
protein to form chromatin, the fundamental unit of which is the nucleosome core particle (NCP). An NCP consists of two copies each of the four core histones H2A, H2B, H3, and H4. This histone octamer binds 147 base pairs of DNA around its outer surface in 1.65 tight superhelical turns (Fig. 1A) (Luger et al. 1997; Richmond and Davey 2003).
Chakravarthy, S, Bao, Y, Roberts, V A, Tremethick, David, Luger, Karolin   +4 more
openaire   +3 more sources

Inferring structural variant cancer cell fraction

Nature Communications, 2020
The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, PCAWG Evolution and Heterogeneity Working Group, Niall M. Corcoran, Tony Papenfuss, Christopher M. Hovens, Florian Markowetz, Geoff Macintyre, PCAWG Consortium   +10 more
doaj   +1 more source

PRINCESS: comprehensive detection of haplotype resolved SNVs, SVs, and methylation

Genome Biology, 2021
Long-read sequencing has been shown to have advantages in structural variation (SV) detection and methylation calling. Many studies focus either on SV, methylation, or phasing of SNV; however, only the combination of variants provides a comprehensive ...
Medhat Mahmoud, Harshavardhan Doddapaneni, Winston Timp, Fritz J. Sedlazeck   +3 more
doaj   +1 more source