Results 51 to 60 of about 374,677 (247)

Clinical Impact of Molecular Subtyping of Pancreatic Cancer

Frontiers in Cell and Developmental Biology, 2021
Pancreatic ductal adenocarcinoma is a highly lethal malignancy, which has now become the seventh most common cause of cancer death in the world, with the highest mortality rates in Europe and North America.
Xu Zhou, Xu Zhou, Kai Hu, Kai Hu, Peter Bailey, Peter Bailey, Peter Bailey, Christoph Springfeld, Susanne Roth, Roma Kurilov, Benedikt Brors, Benedikt Brors, Thomas Gress, Malte Buchholz, Jingyu An, Jingyu An, Kongyuan Wei, Kongyuan Wei, Teresa Peccerella, Teresa Peccerella, Markus W. Büchler, Thilo Hackert, John P. Neoptolemos, John P. Neoptolemos   +23 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genome-Wide Structural Variation Analysis and Breed Comparison of Local Domestic Ducks in Shandong Province, China

Animals
Structural variations in the duck genome significantly impact the environmental adaptability and phenotypic diversity of duck populations. Characterizing these SVs in local domestic duck breeds from Shandong province offers valuable insights for breed ...
Pengwei Ren, Meixia Zhang, Muhammad Zahoor Khan, Liu Yang, Yadi Jing, Xiang Liu, Xiaohui Yang, Chaoran Zhang, Min Zhang, Zhiming Zhu, Nenzhu Zheng, Lujiao Zhang, Shuer Zhang, Mingxia Zhu   +13 more
doaj   +1 more source

MetaSVs: A pipeline combining long and short reads for analysis and visualization of structural variants in metagenomes

iMeta, 2023
Structural variants (SVs, including large‐scale insertions, deletions, inversions, and translocations) significantly impact the functions of genes in the microbial genome, and SVs in the microbiome are associated with diverse biological processes and ...
Yuejuan Li, Jiabao Cao, Jun Wang
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A Multi-Approach for In Silico Detection of Chromosome Inversions in Mosquito Vectors

Microorganisms
In Brazil, Nyssorhynchus darlingi stands out as the primary malaria vector. Chromosome inversions have long been recognized as critical evolutionary mechanisms in diverse organisms.
Marcus Vinicius Niz Alvarez, Filipe Trindade Bozoni, Diego Peres Alonso, Paulo Eduardo Martins Ribolla   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Identification of deleterious variants associated with male infertility genes in a cohort of idiopathic hypospermatogenesis patients

Frontiers in Reproductive Health
IntroductionHypospermatogenesis is a common histopathological subtype of non-obstructive azoospermia and is characterized by a decrease in the total number of germ cells within the seminiferous tubule as a result of spermatogenic failure.
Nisha Sharma, Ashutosh Halder, Seema Kaushal, Manoj Kumar, Manish Jain   +4 more
doaj   +1 more source