Results 141 to 150 of about 15,084,422 (295)
Strategic targeting of Cas9 nickase expands tandem gene arrays
Cell GenomicsSummary: Expanding tandem gene arrays facilitates adaptation through dosage effects and gene family formation via sequence diversification. However, experimental induction of such expansions remains challenging.
Hiroaki Takesue +5 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Genomics CommunicationsStructural variations (SVs) provide a material basis for genomic evolution, which can influence gene expression and three-dimensional (3D) genome structure, and even alter complex chromosomal features through regional recombination, copy number variation,
Weiyao Chen +9 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
, 1918 Mode of access: Internet.Environ Dsgn TH1.A6: v.1: Gift of John Galen Howard"A revised reprint from the 12 issues for 1917 of the Journal of the American Institute of Architects, Structural Service Department.
American Institute of Architects. Structural Service Dept.
core
Pan-Genome-Based Characterization of the PYL Transcription Factor Family in Populus
PlantsAbscisic acid (ABA) is a key phytohormone involved in regulating plant growth and responses to environmental stress. As receptors of ABA, pyrabactin resistance 1 (PYR)/PYR1-like (PYL) proteins play a central role in initiating ABA signal transduction. In
Xiaoli Han +6 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Variation among aged whites and blacks in use of long-term care: A kinship structural approach.
, 2004 Variation among aged whites and blacks in use of long-term care: A kinship structural ...
Min. Li (7988723)
core +4 more sources
BiologyPigs are a major source of animal protein and an important model for studying domestication, adaptation, and the genetics of complex traits. Over the past decade, pig genomics has progressed from generating reference assemblies and variant catalogues ...
Shengguo Tang +7 more
doaj +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source