Results 121 to 130 of about 2,462,103 (310)

Structure, stability and stress properties of amorphous and nanostructured carbon films

, 2006
Structural and mechanical properties of amorphous and nanocomposite carbon are investigated using tight-binding molecular dynamics and Monte Carlo simulations.
Alam, Banhart, Barborini, C. Mathioudakis, Djordjević, Djordjević, Donadio, Drabold, Fallon, Ferrari, Ferrari, Ferrari, Franzblau, Frauenheim, Friedmann, Fyta, G. Kopidakis, Gruen, He, Kalish, Kelires, Kelires, Kelires, Kelires, Lifshitz, M.G. Fyta, Marks, Mathioudakis, McKenzie, McKenzie, Murnaghan, P.C. Kelires, Phillips, Raty, Ravagnan, Robertson, Schultrich, Schwan, Silva, Subramoney, Sullivan, Tang, Tersoff, Thorpe, Vanderbilt, Wooten, Xu, Zhou   +47 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Single-cell structural variations [PDF]

Nature Methods, 2020
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

novoBreak: local assembly for breakpoint detection in cancer genomes. [PDF]

, 2017
We present novoBreak, a genome-wide local assembly algorithm that discovers somatic and germline structural variation breakpoints in whole-genome sequencing data.
Boutros, Paul, Chen, Junjie, Chen, Ken, Chen, Tenghui, Chong, Zechen, Ding, Li, Fan, Xian, Gao, Min, Lee, Anna Y, Ruan, Jue, Zhou, Wanding   +10 more
core  

Multi-Contrast MRI Reconstruction with Structure-Guided Total Variation

, 2015
Magnetic resonance imaging (MRI) is a versatile imaging technique that allows different contrasts depending on the acquisition parameters. Many clinical imaging studies acquire MRI data for more than one of these contrasts---such as for instance T1 and ...
Betcke, Marta M., Ehrhardt, Matthias J.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The complete chloroplast genome sequence of Enkianthus perulatus (Miq.) C.K.Schneid. (Ericaceae)

Mitochondrial DNA. Part B. Resources
Enkianthus perulatus (Miq.) C.K.Schneid. is a popular ornamental plant in Japan, for which the chloroplast genome has not been previously reported. Its complete chloroplast genome was therefore determined, using a high-throughput sequencing technique ...
Watanabe Yoichi
doaj   +1 more source

Gold Standard Gravity [PDF]

This paper provides striking confirmation of the restrictions of the structural gravity model of trade. Structural forces predicted by theory explain 95% of the variation of the fixed effects used to control for them in the recent gravity literature ...
James E. Anderson, Yoto V. Yotov
core  

Algorithms for envelope estimation

, 2014
Envelopes were recently proposed as methods for reducing estimative variation in multivariate linear regression. Estimation of an envelope usually involves optimization over Grassmann manifolds. We propose a fast and widely applicable one-dimensional (1D)
Cook, R. Dennis, Zhang, Xin
core   +2 more sources