Results 101 to 110 of about 5,946,777 (312)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A nanometre-scale non-periodic structural variation in high temperature superconducting ceramics and the implications for properties

, 2001
Non-periodic structural variation has been found in the high Tc cuprates, YBa2Cu3O7-x and Hg0.67Pb0.33Ba2Ca2Cu 3O8+δ, by image analysis of high resolution transmission electron microscope (HRTEM) images.
J. C. Barry, J. A. Alarco, Barry, J. C., Alarco, J. A.   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structural studies of human cell surface receptors: On low-density lipoprotein receptor-related protein 1 and epidermal growth factor receptors 2 and 3 [PDF]

, 2017
The elucidation of proteins’ structure and function is of great importance for the understanding of disease triggering mechanisms and for the development of new drugs. In this thesis, different biophysical and biochemical techniques were employed to gain
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, De Nardis, C.   +2 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Structural service book.

, 1918
Mode of access: Internet.Environ Dsgn TH1.A6: v.1: Gift of John Galen Howard"A revised reprint from the 12 issues for 1917 of the Journal of the American Institute of Architects, Structural Service Department.
American Institute of Architects. Structural Service Dept.
core  

Understanding the first steps of the complement classical pathway: Structural studies on C1-antibody complexes [PDF]

, 2018
The complement system is a complex network of plasma and membrane-associated proteins, which can produce effective immune responses to infectious micro-organisms. Deficiencies of complement proteins cause diseases like systemic lupus erythematosus (SLE),
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, Ugurlar, D.   +2 more
core  

Eliciting Big Data From Small, Young, or Non-standard Languages: 10 Experimental Challenges [PDF]

, 2019
The aim of this work is to identify and analyze a set of challenges that are likely to be encountered when one embarks on fieldwork in linguistic communities that feature small, young, and/or non-standard languages with a goal to elicit big sets of rich ...
Leivada, Evelina, D'Alessandro, R.A.G., Grohmann, Kleanthes, LS Linguistics: Syntax & language Variat, Kleanthes K. Grohmann, Grohmann, Kleanthes K., Roberta D’Alessandro, D'Alessandro, Roberta, ILS Variation, Evelina Leivada   +9 more
core   +2 more sources