Results 101 to 110 of about 3,751,240 (350)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

La cuarta exclusión. Notas sobre lingüística formal

open access: yesLexis, 2015
Formal linguistics is posible only if a program of three exclusions is put into place: exclusion of reference, diachrony and the Subject. The first one to embrace this program was Saussure and then, the different versions of structuralism followed suite.
Mario Montalbetti
doaj  

Structuralism, Empiricism, and Newman's Objection

open access: yesPrincipia: An International Journal of Epistemology, 2019
Newman’s objection can be used to argue that structuralism fails to specify a unique structure for the unobservable world, and hence, one can argue, it is ultimately a trivial task to determine the structure that the world ultimately has. Provided there
Otávio Bueno, Thomas Meier
doaj   +1 more source

Structural Invariants, Structural Kinds, Structural Laws [PDF]

open access: yes, 2012
The paper has three parts. In the first part ExtOSR, an extended version of Ontic Structural Realism, will be introduced. ExtOSR considers structural properties as ontological primitives, where structural properties are understood as comprising both relational and structurally derived intrinsic properties or structure invariants.
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structuralist nspired Research of Folk Religion in Serbia

open access: yesEtnoantropološki Problemi, 2009
This paper discusses application of structuralist methodology to the research of folk region in Serbia. I discussed possible anticipations and the beginning of application of structural methodology; period of high popularity of rites of passage theories
Danijel Sinani
doaj   +1 more source

Mathematical Representation: Playing a Role [PDF]

open access: yes, 2013
The primary justification for mathematical structuralism is its capacity to explain two observations about mathematical objects, typically natural numbers. Non-eliminative structuralism attributes these features to the particular ontology of mathematics.
Hodesdon, Kate
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The structuralist tradition in economics: methodological and macroeconomics aspects

open access: yesBrazilian Journal of Political Economy, 2015
This paper examines the structuralist tradition in economics, emphasizing the role that structures play in the economic growth of developing countries.
FABRÍCIO MISSIO   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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