Results 91 to 100 of about 68,987 (297)

Writing new scripts: redefining managerial agency in Cuba [PDF]

Transitional societies are faced with particularly challenging and pressing problems. These usually involve the passage from a centralised, socialist-based society, to a decentralised, market-based economy. This paper addresses a somewhat different case:
Cunha, Miguel Pina e, Cunha, Rita Campus e   +1 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

"Open Innovation" and "Triple Helix" Models of Innovation: Can Synergy in Innovation Systems Be Measured? [PDF]

, 2016
The model of "Open Innovations" (OI) can be compared with the "Triple Helix of University-Industry-Government Relations" (TH) as attempts to find surplus value in bringing industrial innovation closer to public R&D.
A Giddens, A Petersen, B Carlsson, B Lengyel, BR Clark, C Freeman, CE Shannon, D Sahal, DH Meadows, DM Dubois, DR Brooks, E Bruckner, E Schrödinger, EG Carayannis, ES Andersen, G Dosi, G Simmel, H Bathelt, H Etzkowitz, H Etzkowitz, H Etzkowitz, H Etzkowitz, H Foerster von, H Theil, HW Chesbrough, I Ivanova, IA Ivanova, J Sábato, JFG Bunders, K Krippendorff, L Brillouin, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, MA Hajer, N Abramson, N Luhmann, N Luhmann, N Rosenberg, P Cooke, R Rosen, RD Whitley, RE Ulanowicz, RR Nelson, S Breschi, S Kline, SA Kauffman, T Vinig, W Daele van den, Y Hayami, Ø Strand   +60 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The structuration theory of Anthony Giddens: a brief reading of some influences arising from the sociological literature

Revista Sem Aspas, 2015
This article is intended to conduct a reading on the structuration theory of Anthony Giddens in order to identify some points of influence of the sociological literature - developed until then - on his theory.
Tailon Rodrigues Almeida
doaj  

The future of information systems-using social systems to create protocols for the virtual environment (systems analysis through social analysis) [PDF]

, 1996
Information is the medium for communication, power-play, politics, and the building block for knowledge systems. It is associated with social interaction, and can be mediated by technology use. The paper argues that the key to understanding the impact of
Conkar, T, Kimble, C
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Dynamics of Affordances and Implications for Design [PDF]

, 2008
Affordance is an important concept in HCI. There are various interpretations of affordances but it has been difficult to use this concept for design purposes.
Chisalita, Christina M., Dix, Alan, Vyas, Dhaval   +2 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source