Results 131 to 140 of about 3,626,748 (297)
PHYSICO-CHEMICAL OPTIMIZATION AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF ALDEHYDE-DERIVED N-ACYLHYDRAZONES: TOWARDS THE IMPROVEMENT OF MODERATE METAL CHELATORS AS A STRATEGY AGAINST METAL-ENHANCED AGGREGOPATHIES [PDF]
, 2021 Daphne S. Cukierman
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FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
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Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
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Relationship between Electronic Structure and Cytotoxic Activity of Azulenequinones and Trihaloacetylazulenes [PDF]
, 2007 The relationship between the structure and cytotoxicactivity of azulenequinones and trihaloacetylazulenes wasinvestigated based on theoretical calculations.
佐藤, 理絵 +5 more
core
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
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Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
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Aging and Cancer, EarlyView.This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
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Preferred Solution Conformation of des‐Arg9‐Bradykinin and Analysis of Structure‐Conformation‐Activity Relationships in the Series [Alan]des‐Arg9‐Bradykinin [PDF]
, 1982 Vincent Dive +4 more
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New Directions for Adult and Continuing Education, EarlyView.ABSTRACT This article explores how artificial intelligence (AI) can support online adult learning by aligning with Knowles’ four principles of andragogy: involvement, experience, problem‐centeredness, and relevance. Three activities were analyzed using a comparative case study (CCS) method.
Xi Lin, Steve W. Schmidt
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