Results 131 to 140 of about 946,801 (258)

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Benzotriazole in Cancer: A Systematic Review on Preclinical Evidence and Structure-Activity Relationship. [PDF]

Pharmaceuticals (Basel)
Mardale G, Prodea A, Munteanu A, Jorgovan M, Mardale S, Dumitrascu VC, Șoica C.   +6 more
europepmc   +1 more source

Additional file 3 of Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

, 2020
Liang‐Chin Huang, Wayland Yeung, Ye Wang, Huimin Cheng, Aarya Venkat, Sheng Li, Ping Ma, Khaled Rasheed, Natarajan Kannan   +8 more
openalex   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Structure-Activity Relationship of the Diaminobutyric Acid Residues in Polymyxins. [PDF]

JACS Au
Ma W, Jiang X, Mu K, Tian S, Yu HH, Wickremasinghe H, Velkov T, Roberts KD, Patil NA, Li J.   +9 more
europepmc   +1 more source

Additional file 5 of Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

, 2020
Liang‐Chin Huang, Wayland Yeung, Ye Wang, Huimin Cheng, Aarya Venkat, Sheng Li, Ping Ma, Khaled Rasheed, Natarajan Kannan   +8 more
openalex   +1 more source

Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis [PDF]

, 2014
Shahul Hameed P, Suresh Solapure, Kakoli Mukherjee, Vrinda Nandi, David Waterson, Radha Krishan Shandil, Meenakshi Balganesh, Vasan K. Sambandamurthy, Anand Kumar Raichurkar, Abhijeet Deshpande, Anirban Ghosh, Disha Awasthy, Gajanan Shanbhag, Gulebahar Sheikh, Helen McMiken, Jayashree Puttur, Jitendar Reddy, Jim Werngren, Jon Read, Mahesh Kumar, R Manjunatha, Murugan Chinnapattu, Prashanti Madhavapeddi, Praveena Manjrekar, Reetobrata Basu, Sheshagiri Gaonkar, Sreevalli Sharma, Sven Hoffner, Vaishali Humnabadkar, Venkita Subbulakshmi, Vijender Panduga   +30 more
openalex   +1 more source

Current development of 1,2,3-triazole derived potential antimalarial scaffolds: Structure- activity relationship (SAR) and bioactive compounds

, 2023
S. Maheen Abdul Rahman, Jasvinder Singh Bhatti, Suresh Thareja, Vikramdeep Monga   +3 more
openalex   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure-Activity Relationship. [PDF]

Influenza Other Respir Viruses
Safratova M, Chen YL, Hostalkova A, Chlebek J, Hsieh CF, Chen BH, Cahlikova L, Kosturko S, Backlund A, Horng JT, Hwang TL, Korinek M.   +11 more
europepmc   +1 more source