Quantitative structureâactivity relationship (QSAR) analysis of aromatic effector specificity in NtrC-like transcriptional activators from aromatic oxidizing bacteria [PDF]
FEMS Microbiology Letters, 2003 A quantitative structure-activity relationship (QSAR) approach was taken to provide mechanistic insights into the interaction between the chemical structure of inducing compounds and the transcriptional activation of aromatic monooxygenase operons among the XylR/DmpR subclass of bacterial NtrC-like transcriptional regulators. Compared to XylR and DmpR,
Park, Joonhong +3 more
openaire +3 more sources
Frontiers in Pharmacology, 2022 Astragali Radix polysaccharides (APSs) have a wide range of biological activities. Our preliminary experiment showed that APS-Ⅱ (10 kDa) was the main immunologically active component of APSs.
Ke Li +29 more
doaj +1 more source
Absorption of Unconjugated Bile Acids from the Perfused Jejunum of the Anesthetized Rat: Structure–Activity Relationships and Rate‐Limiting Steps [PDF]
Lipids, 2018 Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/145508/1/lipd12052_am.pdf ; https://deepblue.lib.umich.edu/bitstream/2027.42/145508/2/lipd12052 ...
Dupas, Jean‐louis +2 more
openaire +3 more sources
Pharmaceuticals, 2021 A significant number of the anti-inflammatory drugs currently in use are becoming obsolete. These are exceptionally hazardous for long-term use because of their possible unfavourable impacts.
R. Veerasamy +3 more
semanticscholar +1 more source
Journal of Biomolecular Structure and Dynamics, 2020 Computer-aided drug screening by molecular docking, molecular dynamics (MD) and structural–activity relationship (SAR) can offer an efficient approach to identify promising drug repurposing candidates for COVID-19 treatment.
M. Rahman +12 more
semanticscholar +1 more source
Molecules, 2023 To investigate and compare the pharmacokinetic profile and anti-cancer activity of fluorinated and iodinated photosensitizers (PSs), the 3-(1′-(o-fluorobenzyloxy)ethyl pyropheophorbide and the corresponding meta-(m-) and para (p-) fluorinated analogs ...
Taur Prakash Pandurang +8 more
doaj +1 more source
Structure - Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis
Journal of Pure and Applied Microbiology, 2017 Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan Purkan +4 more
doaj +1 more source
Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents [PDF]
Journal of the Serbian Chemical Society, 2011 A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature.
Trišović Nemanja +7 more
doaj +1 more source
Targeting intracellular, multi-drug resistant Staphylococcus aureus with guanidinium polymers by elucidating the structure-activity relationship [PDF]
, 2019 Intracellular persistence of bacteria represents a clinical challenge as bacteria can thrive in an environment protected from antibiotics and immune responses. Novel targeting strategies are critical in tackling antibiotic resistant infections. Synthetic
Hartlieb, Matthias +6 more
core +1 more source
Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]
, 2020 β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik +4 more
core +2 more sources