Results 31 to 40 of about 1,492,525 (254)

Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(−)-Zampanolide Analogs

, 2023
We have prepared a series of partially reduced or demethylated analogs of the natural microtubule stabilizer (−)-zampanolide and we have assessed their antiproliferative activity, their microtubule-binding affinity and their effects on the cellular ...
Simone, Berardozzi, Bernhard, Pfeiffer, John H., Miller, Sandro, Pagani, Mariano, Redondo-Horcajo, J. Fernando, Díaz, Daniel, Lucena-Agell, Karl-Heinz, Altmann, Tobias Michael, Brütsch, Etienne, Cotter, Carolina, Davies   +10 more
core   +1 more source

Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex

Journal of Future Foods
Glycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities.
Yu Zhong, Jiangxiong Zhu, Bifen Zhu, Hao Yin, Danfeng Wang, Yun Deng, Minyan Zhang, Chunrong Zhang   +7 more
doaj   +1 more source

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP

Drug Design, Development and Therapy, 2022
Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian ...
Wang L
doaj  

Expedient Synthesis of a Library of Heparan Sulfate Like “Head to Tail” Linked Multimers for Structure and Activity Relationship Studies

, 2022
Heparan sulfate (HS) plays significant roles in various biological processes such as inflammation, cell proliferation, and bacterial and viral infection. The inherent complexity of naturally existing HS has severely hindered the thorough understanding of
Chang-xin, Huo, Fuming, Zhang, Kedar, Baryal, Linda, Hsieh-wilson, Li, Liang, Weizhun, Yang, Jian, Liu, Xuefei, Huang, Jicheng, Zhang, Robert, Linhardt, Sherif, Ramadan, Jamie, Bernard   +11 more
core   +1 more source

Flavonoids as inhibitors of human neutrophil elastase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells.
Katarzyna Jakimiuk, Jakub Gesek, Atanas G. Atanasov, Michał Tomczyk   +3 more
doaj   +1 more source

Synthesis, antimicrobial screening and structure–activity relationship of novel pyrimidines and their thioethers

Bulletin of Faculty of Pharmacy Cairo University, 2014
In the present study, a series of novel pyrimidines (1) and their thioethers (2–5) were synthesized. Structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR mass spectral data and elemental analysis.
Chetan M. Bhalgat, B. Ramesh
doaj   +1 more source

MOESM1 of Quantitative structureâ activity relationship to predict the anti-malarial activity in a set of new imidazolopiperazines based on artificial neural networks

, 2019
Additional file 1.Additional tables.
Yousefinejad, Saeed, Mahboubifar, Marjan, Eskandari, Rayhaneh   +2 more
openaire   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Anticancer activity of natural cytokinins: a structure-activity relationship study

, 2010
Cytokinin ribosides (N(6)-substituted adenosine derivatives) have been shown to have anticancer activity both in vitro and in vivo. This study presents the first systematic analysis of the relationship between the chemical structure of cytokinins and ...
Dolezal, Karel, Krystof, Vladimír, Lenobel, René, Hajdúch, Marián, Dzubák, Petr, Strnad, Miroslav, Spíchal, Lukás, Niemann, Percy, Zatloukal, Marek, Voller, Jirí, Béres, Tibor   +10 more
core   +1 more source

Research Progress on Structure, Activity and Structure-Activity Relationship of Sea Cucumber Polysaccharides [PDF]

Shipin Kexue
The sea cucumber is an invertebrate with significant economic value and is extensively consumed as a tonic food in Asian countries due to its high nutritional value.
SHU Zhiqiang, LIU Fang, JING Yuexin, JIAO Chunna, JI Yizhi, WANG Maojian, WANG Gongming, ZHANG Jian
doaj   +1 more source