Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity
Molecules, 2021 Harringtonolide (HO), a natural product isolated from Cephalotaxus harringtonia, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives ...
Xiutao Wu +6 more
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Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations [PDF]
, 2014 The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐
Emery, R +5 more
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MOESM1 of Structureâ activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines
, 2019 Additional file 1. Molecular structures, details of the syntheses and purification procedures as well as characterization data of all new products.
Masch, Andreas +9 more
openaire +1 more source
Clique topology reveals intrinsic geometric structure in neural correlations [PDF]
, 2015 Detecting meaningful structure in neural activity and connectivity data is challenging in the presence of hidden nonlinearities, where traditional eigenvalue-based methods may be misleading. We introduce a novel approach to matrix analysis, called clique
Curto, Carina +3 more
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Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]
, 2020 β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik +4 more
core +2 more sources
Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex
Journal of Future FoodsGlycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities.
Yu Zhong +7 more
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Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]
, 2013 Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S +6 more
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Flavonoids as inhibitors of human neutrophil elastase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells.
Katarzyna Jakimiuk +3 more
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Relating Anaerobic Digestion Microbial Community and Process Function [PDF]
, 2016 Anaerobic digestion (AD) involves a consortium of microorganisms that convert substrates into biogas containing methane for renewable energy. The technology has suffered from the perception of being periodically unstable due to limited understanding of ...
Bocher, Benjamin T.W. +3 more
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Drug Design, Development and Therapy, 2022 Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian ...
Wang L
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