Results 11 to 20 of about 1,492,525 (254)

Electrochemical behavior of indolone-N-oxides: Relationship to structure and antiplasmodial activity [PDF]

, 2012
Indolone-N-oxides exert high parasiticidal activity at the nanomolar level in vitro against Plasmodiumfalciparum, the parasite responsible for malaria.
Perio, Pierre, Fabre, Paul-Louis, Nepveu, Françoise, Montrose, Armelle, Reybier, Karine, Nguyen, Thi Hoang Yen, Ibrahim, Hany   +6 more
core   +1 more source

Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2011
A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature.
Trišović Nemanja, Marković Snežana, Čomić Ljiljana, Božić Biljana, Ušćumlić Gordana, Stefanović Olgica, Božić Bojan, Obradović Ana   +7 more
doaj   +1 more source

A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity

Molecules, 2023
To investigate and compare the pharmacokinetic profile and anti-cancer activity of fluorinated and iodinated photosensitizers (PSs), the 3-(1′-(o-fluorobenzyloxy)ethyl pyropheophorbide and the corresponding meta-(m-) and para (p-) fluorinated analogs ...
Taur Prakash Pandurang, Joseph Cacaccio, Farukh A. Durrani, Mykhaylo Dukh, Ajyal Z. Alsaleh, Munawwar Sajjad, Francis D’Souza, Dalip Kumar, Ravindra K. Pandey   +8 more
doaj   +1 more source

Structure-Activity Relationship and Bioactivity Studies of Neurotrophic trans-Banglene

, 2021
Neurotrophic small molecule natural products are functional analogs of signaling proteins called neurotrophins, which cause a pro-growth, pro-survival, or pro-differentiation response in neuronal cells.
Khyati, Gohil, Florence, Williams, M. Zain, Kazmi   +2 more
core   +1 more source

Structure-activity relationship studies of arylsulfoxides as reversible monoacylglycerol lipase inhibitors

, 2023
Monoacylglyerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). The central role of MAGL in the metabolism of 2-AG makes it an attractive therapeutic target for a variety of disorders, including ...
Renze, Bakker, Avand, Amedi, Mirjam, Huizenga, Richard, van der Berg, Hui, Deng, Mario, van der Stelt, Ming, Jiang, Florian, Mohr, Constant, van Boeckel, Tom, van der Wel   +9 more
core   +1 more source

Investigating the Structure–Activity Relationship of the Insecticidal Natural Product Rocaglamide

CHIMIA, 2017
The natural product Rocaglamide (1), isolated from the tree Aglaia elliptifolia, is a compelling but also challenging lead structure for crop protection.
Roger G. Hall, Ian Bruce, Nigel G. Cooke, Louis J. Diorazio, Fredrik Cederbaum, Markus R. Dobler, Ed Irving   +6 more
doaj   +1 more source

Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives

Molecules, 2015
A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi.
Zhibin Li, Shaohua Chen, Shaowen Zhu, Jianjun Luo, Yaomou Zhang, Qunfang Weng   +5 more
doaj   +1 more source

Synthesis and leishmanicidal activity of cinnamic acid esters: structure–activity relationship [PDF]

, 2014
Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcohols. Structures of the products were elucidated by spectroscopic analysis.
Vélez, Iván D., Robledo, Sara M., Diaz-Oltra, Santiago, Cardona G, Wilson I, Paños Pérez, Julián, Cardona Galeano, Wilson Isidro, Muñoz, Diana, Otero, Elver, Carda, Miguel   +8 more
core   +1 more source

Synthesis and Antibacterial Evaluation of N-phenylacetamide Derivatives Containing 4-Arylthiazole Moieties

Molecules, 2020
A series of new N-phenylacetamide derivatives containing 4-arylthiazole moieties was designed and synthesized by introducing the thiazole moiety into the amide scaffold.
Hui Lu, Xia Zhou, Lei Wang, Linhong Jin
doaj   +1 more source

Quantitative Structure Activity Relationship (QSAR) study predicts small molecule binding to RNA structure

, 2021
The diversity of RNA structural elements and their documented role in human diseases make RNA an attractive therapeutic target. However, progress in drug discovery and development has been hindered by challenges in the determination of high-resolution ...
Martina, Zafferani, Zhengguo, Cai, Amanda, Hargrove, Olanrewaju, Akande   +3 more
core   +1 more source