Results 11 to 20 of about 17,685,797 (244)

Structure - Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis [PDF]

Journal of Pure and Applied Microbiology, 2017
Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan Purkan, Sri Puji Astuti Wahyuningsih, Wiwin Retnowati, Diah Amelia, Alfain Noerdin Alimny   +4 more
doaj   +4 more sources

Biological activity, quantitative structure–activity relationship analysis, and molecular docking of xanthone derivatives as anticancer drugs

Drug Design, Development and Therapy, 2018
Isnatin Miladiyah,1,2 Jumina Jumina,3 Sofia Mubarika Haryana,4 Mustofa Mustofa5 1Pharmacology Department, Faculty of Medicine, Islamic University of Indonesia, 2Doctorate Program of Medical Science and Health, Faculty of Medicine, 3Chemistry Department,
Miladiyah I, Jumina J, Haryana SM, Mustofa M   +3 more
doaj   +1 more source

Synthesis, Biological Evaluation and Structure–Activity Relationship of Juglone Derived Naphthoquinones as Potential Antipsoriatic Agents [PDF]

Biomolecules
Psoriasis is a chronic, immune-mediated inflammatory skin disease for which the development of structurally novel and accessible small-molecule candidates remains of considerable interest. In this study, a series of juglone-derived naphthoquinone analogs
Tong Bu, Zile Gong, Yudong Ma, Lixia Dai, Yuchao Ma, Xiaoyan Yu, Xiaorong Yang, Xiaolou Miao, Xiaofei Shang   +8 more
doaj   +2 more sources

Metabolic profile and structure–activity relationship of resveratrol and its analogs in human bladder cancer cells

Cancer Management and Research, 2019
Yang Yang,1,2 Guangyuan Zhang,2 Chuangang Li,3 Sihan Wang,2 Manning Zhu,2 Jinan Wang,2 Hangtian Yue,2 Xiaodong Ma,2 Yuhong Zhen,2 Xiaohong Shu1,21College of Integrative Medicine, Dalian Medical University, Dalian 116044, People’s Republic of China;
Yang Y, Zhang G, Li C, Wang S, Zhu M, Wang J, Yue H, Ma X, Zhen Y, Shu X   +9 more
doaj   +1 more source

Structure-Activity Relationship in NOD2 Agonistic Muramyl Dipeptides [PDF]

, 2023
Nucleotide-binding oligomerization domain 2 (NOD2) is a receptor of the innate immune system that is capable of perceiving bacterial and viral infections.
Aarzoo, Kamboj, Nikolai, Petrovsky, Madhuri, Patil, Deepak, Salunke   +3 more
core   +1 more source

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Biomolecules, 2022
Alkaloids are a wide family of basic N-containing natural products, whose research has revealed bioactive compounds of pharmacological interest. Studies on these compounds have focused more attention on those produced by plants, although other types of ...
Jesús G. Zorrilla, Antonio Evidente
doaj   +1 more source

Structural characteristics of microbial exopolysaccharides in association with their biological activities: a review

Chemical and Biological Technologies in Agriculture, 2023
Many microbial exopolysaccharides (EPS) have been reported in the last decade, and their fermentation processes, functional properties and applications, structural characterization, and biological activities have been extensively studied.
Wei Wang, Yuhao Ju, Nan Liu, Shengbo Shi, Lujiang Hao   +4 more
doaj   +1 more source

Design, Synthesis, and Bioactivity of Novel Quinazolinone Scaffolds Containing Pyrazole Carbamide Derivatives as Antifungal Agents

Current Issues in Molecular Biology, 2022
In this study, 32 novel quinazolinone-scaffold-containing pyrazole carbamide derivatives were designed and synthesized in a search for a novel fungicide against Rhizoctonia solani.
Zhiwei Lei, Jianmei Yao, Huifang Liu, Xianjin Bai, Xingsi Gao, Qiuyuan Pan, Wen Yang   +6 more
doaj   +1 more source

Anti-Neurodegenerating Activity: Structure–Activity Relationship Analysis of Flavonoids

Molecules, 2023
An anti-neurodegeneration activity study was carried out for 80 flavonoid compounds. The structure–activity analysis of the structures was carried out by performing three different anti-neurodegeneration screening tests, showing that in these structures,
Gagan Preet, Ahlam Haj Hasan, Piteesha Ramlagan, Shameem Fawdar, Fabien Boulle, Marcel Jaspars   +5 more
doaj   +1 more source

Structure-Activity Relationship and Bioactivity Studies of Neurotrophic trans-Banglene [PDF]

, 2021
Neurotrophic small molecule natural products are functional analogs of signaling proteins called neurotrophins, which cause a pro-growth, pro-survival, or pro-differentiation response in neuronal cells.
Khyati, Gohil, Florence, Williams, M. Zain, Kazmi   +2 more
core   +2 more sources