Frontiers in Pharmacology, 2022 Astragali Radix polysaccharides (APSs) have a wide range of biological activities. Our preliminary experiment showed that APS-Ⅱ (10 kDa) was the main immunologically active component of APSs.
Ke Li +29 more
doaj +1 more source
Quantitative structureâactivity relationship (QSAR) analysis of aromatic effector specificity in NtrC-like transcriptional activators from aromatic oxidizing bacteria [PDF]
FEMS Microbiology Letters, 2003 A quantitative structure-activity relationship (QSAR) approach was taken to provide mechanistic insights into the interaction between the chemical structure of inducing compounds and the transcriptional activation of aromatic monooxygenase operons among the XylR/DmpR subclass of bacterial NtrC-like transcriptional regulators. Compared to XylR and DmpR,
Park, Joonhong +3 more
openaire +3 more sources
Structure-activity relationship studies of arylsulfoxides as reversible monoacylglycerol lipase inhibitors [PDF]
, 2023 Monoacylglyerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). The central role of MAGL in the metabolism of 2-AG makes it an attractive therapeutic target for a variety of disorders, including ...
Renze, Bakker +9 more
core +2 more sources
Quantitative Structure Activity Relationship (QSAR) study predicts small molecule binding to RNA structure [PDF]
, 2021 The diversity of RNA structural elements and their documented role in human diseases make RNA an attractive therapeutic target. However, progress in drug discovery and development has been hindered by challenges in the determination of high-resolution ...
Martina, Zafferani +3 more
core +2 more sources
Electrochemical behavior of indolone-N-oxides: Relationship to structure and antiplasmodial activity [PDF]
, 2012 Indolone-N-oxides exert high parasiticidal activity at the nanomolar level in vitro against Plasmodiumfalciparum, the parasite responsible for malaria.
Perio, Pierre +6 more
core +1 more source
Comprehensive Structure-Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations [PDF]
, 2022 The cepafungins are a class of highly potent and selective eukaryotic proteasome inhibitor natural products with potential to treat refractory multiple myeloma and other cancers.
Hans, Renata +4 more
core +2 more sources
Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents [PDF]
Journal of the Serbian Chemical Society, 2011 A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature.
Trišović Nemanja +7 more
doaj +1 more source
Molecules, 2023 To investigate and compare the pharmacokinetic profile and anti-cancer activity of fluorinated and iodinated photosensitizers (PSs), the 3-(1′-(o-fluorobenzyloxy)ethyl pyropheophorbide and the corresponding meta-(m-) and para (p-) fluorinated analogs ...
Taur Prakash Pandurang +8 more
doaj +1 more source
Investigating the Structure–Activity Relationship of the Insecticidal Natural Product Rocaglamide
CHIMIA, 2017 The natural product Rocaglamide (1), isolated from the tree Aglaia elliptifolia, is a compelling but also challenging lead structure for crop protection.
Roger G. Hall +6 more
doaj +1 more source
Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives
Molecules, 2015 A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi.
Zhibin Li +5 more
doaj +1 more source