Results 21 to 30 of about 1,492,525 (254)

Design, Synthesis, and Anti-Inflammatory Activities of 12-Dehydropyxinol Derivatives

Molecules, 2023
Pyxinol skeleton is a promising framework of anti-inflammatory agents formed in the human liver from 20S-protopanaxadiol, the main active aglycone of ginsenosides. In the present study, a new series of amino acid-containing derivatives were produced from
Yunxiao Wang, Xiaoliang Mi, Yuan Du, Shuang Li, Liping Yu, Meng Gao, Xiaoyue Yang, Zhihua Song, Hui Yu, Gangqiang Yang   +9 more
doaj   +1 more source

Progress in the Optimization of 4(1H)-Quinolone Derivatives as Antimalarials Targeting the Erythrocytic, the Exoerythrocytic and the Transmitting Stages of the Malaria Parasite

CHIMIA, 2017
Malaria is one of the leading infectious diseases occurring mainly in tropical and subtropical areas. Although available antimalarial tools have reduced the number of fatalities, there is still an urgent need for the development of new and more ...
Fabian Brockmeyer, Roman Manetsch
doaj   +1 more source

Comprehensive Structure-Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations

, 2022
The cepafungins are a class of highly potent and selective eukaryotic proteasome inhibitor natural products with potential to treat refractory multiple myeloma and other cancers.
Hans, Renata, Anton, Shuster, Alexander, Amatuni, Alexander, Adibekian, Daniel, Abegg   +4 more
core   +1 more source

Pyrimidine: a review on anticancer activity with key emphasis on SAR

Future Journal of Pharmaceutical Sciences, 2021
Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra, Tanya Prasad, Tripti Sharma   +2 more
doaj   +1 more source

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop.
Ming Bian, Qian-qian Ma, Yun Wu, Huan-huan Du, Gong Guo-hua   +4 more
doaj   +1 more source

An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources

Molecules, 2022
Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and ...
Yong-Shuai Jing, Yun-Feng Ma, Fei-Bing Pan, Ming-Song Li, Yu-Guang Zheng, Lan-Fang Wu, Dan-Shen Zhang   +6 more
doaj   +1 more source

Improvement of the Oxidative Stability of Rosehip, Hemp, and Passion Fruit Oils by the Addition of Monocyclic Phenols as Antioxidants

Antioxidants
Caffeic, syringic, and protocatechuic acids are phenolic acids with important antioxidant activity. In this work we studied how the oxidative stability of rosehip, hemp, and passion fruit oils improves with the addition of these antioxidant acids.
Gloria Castellano, Irene Sarrión, Carmen Fagoaga, Ricardo M. Giménez-Núñez, Enrique Gómez-Gómez, Francisco Torrens   +5 more
doaj   +1 more source

Additional file 4: of PubChem structureâ activity relationship (SAR) clusters

, 2015
(supplementary_data.pdf): contains Figures S1, S2, and S3.
Sunghwan Kim, Lianyi Han, Yu, Bo, HäHnke, Volker, Bolton, Evan, Bryant, Stephen   +5 more
openaire   +1 more source

Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

Molecules, 2021
Harringtonolide (HO), a natural product isolated from Cephalotaxus harringtonia, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives ...
Xiutao Wu, Lijie Gong, Chen Chen, Ye Tao, Wuxi Zhou, Lingyi Kong, Jianguang Luo   +6 more
doaj   +1 more source

MOESM1 of Structureâ activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

, 2019
Additional file 1. Molecular structures, details of the syntheses and purification procedures as well as characterization data of all new products.
Masch, Andreas, Nasereddin, Abed, Alder, Arne, Bird, Megan, Schweda, Sandra, Preu, Lutz, Doerig, Christian, Dzikowski, Ron, Gilberger, Tim, Kunick, Conrad   +9 more
openaire   +1 more source