Results 221 to 230 of about 3,626,748 (297)

Total Synthesis of Mandelalide A and Synthesis of (–)‐Zampanolide Analogs for Structure‐Activity Relationship Studies

, 2016
Tobias Michael Brà ⁄ tsch
openalex   +2 more sources

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

Structure-Activity Relationship Studies of Emtricitabine Prodrugs toward Long-Acting Antiretroviral Formulations. [PDF]

ACS Omega
Al-Khouja A, Henriquez S, Hobson JJ, White JA, Flexner C, Owen A, Rannard SP, Freel Meyers CL.   +7 more
europepmc   +1 more source

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors

, 2018
Upul K. Bandarage, Jingrong Cao, Jon H. Come, John J. Court, Huai Gao, Marc Jacobs, Craig Marhefka, Suganthi Nanthakumar, Jeremy Green   +8 more
openalex   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Modeling and Interpretability Study of the Structure-Activity Relationship for Multigeneration EGFR Inhibitors. [PDF]

ACS Omega
Sun Z, Huo D, Guo J, Yan A.
europepmc   +1 more source

Synthesis and Biological Activities of Neoechinulin A Derivatives: New Aspects of Structure-Activity Relationships for Neoechinulin A

, 2008
Kouji Kuramochi, Kensuke Ohnishi, Satoshi Fujieda, Mitsuhiro Nakajima, Yoshihiko Saitoh, Nobuo Watanabe, Toshifumi Takeuchi, Atsuo Nakazaki, Fumio Sugawara, Takao Arai, Susumu Kobayashi   +10 more
openalex   +2 more sources

Enhancing Corrosion Resistance and Mechanical Strength of 3D‐Printed Iron Polylactic Acid for Marine Applications via Laser Surface Texturing

Advanced Engineering Materials, EarlyView.
Laser surface texturing significantly improves the corrosion resistance and mechanical strength of 3D‐printed iron polylactic acid (Ir‐PLA) for marine applications. Optimal laser parameters reduce corrosion by 80% and enhance tensile strength by 25% and ductility by 15%.
Mohammad Rezayat, Mojtaba Karamimoghadam, Mohammadreza Lalegani Dezaki, Ali Zolfagharian, Giuseppe Casalino, Antonio Mateo, Mahdi Bodaghi   +6 more
wiley   +1 more source

Exploring Substituted Dihydroxybenzenes as Urease Inhibitors through Structure-Activity Relationship Studies in Soil Incubations. [PDF]

Chempluschem
Nathanael JG, Kang H, Wille U.
europepmc   +1 more source

First‐Principles Modeling of Solid Solution Softening and Hardening Effects in Al–Mg–Zr–Si Aluminum Alloys

Advanced Engineering Materials, EarlyView.
The role of various alloying elements in face‐centered cubic aluminum on the barrier of a Shockley partial dislocation during its motion is presented. The study aims to understand how alloying atoms such as Mg, Si, and Zr affect the energy landscape for dislocation motion, thus influencing the solid solution hardening and softening in aluminum, which ...
Inna Plyushchay, Zhengqing Wei, Nebahat Bulut, Sibylle Gemming   +3 more
wiley   +1 more source