Results 31 to 40 of about 871,001 (271)

MOESM1 of Molecular docking, synthesis, kinetics study, structureâ activity relationship and ADMET analysis of morin analogous as Helicobacter pylori urease inhibitors

, 2019
Additional file 1. Supplementary file for spectral data.
Kataria, Ritu, Anurag Khatkar
openaire   +1 more source

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP

Drug Design, Development and Therapy, 2022
Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian ...
Wang L
doaj  

MOESM1 of Quantitative structureâ activity relationship to predict the anti-malarial activity in a set of new imidazolopiperazines based on artificial neural networks

, 2019
Additional file 1.Additional tables.
Yousefinejad, Saeed, Mahboubifar, Marjan, Rayhaneh Eskandari   +2 more
openaire   +1 more source

Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

Molecules, 2021
Harringtonolide (HO), a natural product isolated from Cephalotaxus harringtonia, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives ...
Xiutao Wu, Lijie Gong, Chen Chen, Ye Tao, Wuxi Zhou, Lingyi Kong, Jianguang Luo   +6 more
doaj   +1 more source

Synthesis, antimicrobial screening and structure–activity relationship of novel pyrimidines and their thioethers

Bulletin of Faculty of Pharmacy Cairo University, 2014
In the present study, a series of novel pyrimidines (1) and their thioethers (2–5) were synthesized. Structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR mass spectral data and elemental analysis.
Chetan M. Bhalgat, B. Ramesh
doaj   +1 more source

Piperazine skeleton in the structural modification of natural products: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications. Over
Run-Hui Zhang, Hong-Yan Guo, Hao Deng, Jinzi Li, Zhe-Shan Quan   +4 more
doaj   +1 more source

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

Population Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

MOESM1 of 4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structureâ activity relationship studies

, 2018
Additional file 1. Additional figures and Tables.
Yusufzai, Samina, Hasnah Osman, Khan, Mohammad, Razik, Basma Abd, Ezzat, Mohammed, Suriyati Mohamad, Sulaiman, Othman, Jualang Gansau, Thaigarajan Parumasivam   +8 more
openaire   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5

Molecules, 2020
Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases. They regulate many physiological processes and play important roles in inflammation, diabetes, cancers, and neurodegeneration diseases.
Haozhen Han, Chunpu Li, Man Li, Lisheng Yang, Sen Zhao, Zhifei Wang, Hong Liu, Dongxiang Liu   +7 more
doaj   +1 more source