Oxidative Medicine and Cellular Longevity, 2020 This study is aimed at determining the relationship of flavonoid structures to their chemical and intracellular antioxidant activities. The antioxidant activities of 60 flavonoids were investigated by three different antioxidant assays, including 2,2 ...
Qiang Zhang +7 more
semanticscholar +1 more source
Application of Hansch’s Model to Capsaicinoids and Capsinoids: A Study Using the Quantitative Structure−Activity Relationship. A Novel Method for the Synthesis of Capsinoids [PDF]
, 2010 We describe a synthetic approach for two families of compounds, the capsaicinoids and capsinoids, as part of a study of the quantitative relationship between structure and ...
Appendino G. +32 more
core +2 more sources
Pyrimidine: a review on anticancer activity with key emphasis on SAR
Future Journal of Pharmaceutical Sciences, 2021 Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra +2 more
doaj +1 more source
Design, Synthesis, and Anti-Inflammatory Activities of 12-Dehydropyxinol Derivatives
Molecules, 2023 Pyxinol skeleton is a promising framework of anti-inflammatory agents formed in the human liver from 20S-protopanaxadiol, the main active aglycone of ginsenosides. In the present study, a new series of amino acid-containing derivatives were produced from
Yunxiao Wang +9 more
doaj +1 more source
A Review of the Structure—Activity Relationship of Natural and Synthetic Antimetastatic Compounds
Biomolecules, 2020 There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic ...
S. K. Liew +3 more
semanticscholar +1 more source
Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations [PDF]
, 2014 The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐
Emery, R +5 more
core +1 more source
CHIMIA, 2017 Malaria is one of the leading infectious diseases occurring mainly in tropical and subtropical areas. Although available antimalarial tools have reduced the number of fatalities, there is still an urgent need for the development of new and more ...
Fabian Brockmeyer, Roman Manetsch
doaj +1 more source
Extensive structure‐activity relationship study of albicidin’s C‐terminal dipeptidic p‐aminobenzoic acid moiety [PDF]
, 2019 Albicidin is a recently described natural product that strongly inhibits bacterial DNA gyrase. The pronounced activity, particularly against Gram‐negative bacteria, turns it into a promising lead structure for an antibacterial drug.
Behroz, Iraj +7 more
core +1 more source
Exploring the Structure–Activity Relationship on Platinum Nanoparticles [PDF]
, 2020 The design of active and stable Pt-based nanoscale electrocatalysts for the oxygen reduction reaction (ORR) plays the central role in ameliorating the efficiency of proton exchange membrane fuel-cells towards future energy applications.
Braunwarth, L., Jacob, T., Jung, C.
core +2 more sources
An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources
Molecules, 2022 Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and ...
Yong-Shuai Jing +6 more
doaj +1 more source