Results 81 to 90 of about 3,626,748 (297)

Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines [PDF]

, 1987
A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Kovacic, Peter, Ryan, Michael D.   +2 more
core   +1 more source

A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections [PDF]

, 2018
Indexación: Scopus.A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class
Alarcón, P., Andrades-Lagos, J., Bollo Dragnic, S., Campanini-Salinas, J., Choquesillo-Lazarte, D., Faúndez, M., Gonzalez Rocha, G., Kogan, M., Mella, J., Recabarren Gajardo, G., Salas-Huenuleo, E., Silva, F., Vidal, R., Vásquez-Velásquez, D.   +13 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Bioinformatics, bacterial expression and enzyme activity analyses of dichloromethane dehalogenase from Methylobacterium rhodesianum H13

Biotechnology & Biotechnological Equipment, 2020
Dechlorination is the key step in biological degradation of dichloromethane (DCM), which is catalyzed by the enzyme DCM dehalogenase. In this study, the detailed structure and function of DCM dehalogenase in Methylobacterium rhodesianum H13 were ...
Jianguo Ni, Ying Liu, Chenjia Shen, Dongzhi Chen, Yueyong Xin, Qi Liu   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Metabolic profile and structure–activity relationship of resveratrol and its analogs in human bladder cancer cells

Cancer Management and Research, 2019
Yang Yang,1,2 Guangyuan Zhang,2 Chuangang Li,3 Sihan Wang,2 Manning Zhu,2 Jinan Wang,2 Hangtian Yue,2 Xiaodong Ma,2 Yuhong Zhen,2 Xiaohong Shu1,21College of Integrative Medicine, Dalian Medical University, Dalian 116044, People’s Republic of China;
Yang Y, Zhang G, Li C, Wang S, Zhu M, Wang J, Yue H, Ma X, Zhen Y, Shu X   +9 more
doaj  

Antifouling Activity of Simple Synthetic Diterpenoids against Larvae of the Barnacle Balanus albicostatus Pilsbry

Molecules, 2010
Five new pimarane diterpenoids 1-5 were synthesized using ent-8(14)-pimarene-15R,16-diol as starting material. The structures were elucidated by means of extensive NMR and MS analysis.
Dan-Qing Feng, Yi-Ming Lin, Jun-De Chen, Cui-Ling Sun, Rui-Zao Yi   +4 more
doaj   +1 more source

Theoretical Study on Highly Active Bifunctional Metalloporphyrin Catalysts for the Coupling Reaction of Epoxides with Carbon Dioxide [PDF]

, 2016
Highly active bifunctional metalloporphyrin catalysts were developed for the coupling reaction of epoxides with CO2 to produce cyclic carbonates. The bifunctional catalysts have both quaternary ammonium halide groups and a metal center.
Ahmadi, Aida, Becke, Castro-Gómez, Chen, Chen, Cokoja, Cokoja, Comerford, D'Elia, Darensbourg, Ema, Ema, Ema, Foltran, Jin, Kielland, Kruper, Lee, Li, Li, Liu, Ma, Maeda, Maeda, Maeda, Martín, Paddock, Qin, Reed, Reed, Rocha, Stewart, Sun, Tlili, Tomasi, Tsuji, Wang, Wang, Wang, Whiteoak, Whiteoak   +41 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source