Results 11 to 20 of about 2,497,356 (41)

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
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Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs

, 2012
By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are
Bortolotto, Carlotti, Chen, Chopra, De Luigi, Doershuk, Duivenvoorden, Dutta, Lambs, McNamara, Nelson, Nelson, Silvia, Stetler-Steveson, Tang, Thong, Wainwright, Yrjanheikki   +17 more
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Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis [PDF]

, 2008
As a continuation of our previous work that turned toward the identification of antimycobacterial compounds with innovative structures, two series of pyrazole derivatives were synthesized by parallel solution-phase synthesis and were assayed as ...
Ahmad, Alessandro De Logu, Beatrice Bechi, Bieringer, Brooks, Burman, Daniele Castagnolo, De Logu, Espinal, Fabrizio Manetti, Frieden, Holzer, Holzer, Janin, Jensen, Kutterer, Lorenza Chisu, Manetti, Manetti, Marco Radi, Matteo Magnani, Maurizio Botta, O’Brien, Rita Meleddu, Sibilla Supino, Smellie, Smellie, Smellie   +27 more
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More on Comparison Between First Geometric-Arithmetic Index and Atom-Bond Connectivity Index [PDF]

, 2015
The first geometric-arithmetic (GA) index and atom-bond connectivity (ABC) index are molecular structure descriptors which play a significant role in quantitative structure-property relationship (QSPR) and quantitative structure-activity relationship ...
Akbar Ali, Akhlaq Ahmad, Bhatti, Zahid Raza   +3 more
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Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]

, 2019
A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
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Quantum chemical properties used in structure-activity relationship studies [PDF]

, 2010
In this work we show that structure-activity relationship studies are of great importance in modern chemistry and biochemistry. In order to obtain a significant correlation, it is crucial that appropriate descriptors be employed.
ARROIO, Agnaldo, HONÓRIO, Káthia M., SILVA, Albérico B. F. da   +2 more
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Quantitative structure-activity relationship for antimalarial activity of artemisinin [PDF]

, 2010
The increase in resistance to older drugs and the emergence of new types of infection have created an urgent need for discovery and development of new compounds with antimalarial activity.
Hasan, Mohamed Noor, Jamaludin, Rosmahaida   +1 more
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Values of sexual behaviour in Central and Eastern Europe [PDF]

, 2002
Despite the profusion of social cognitive models for the prediction of sexual behaviour, we have only limited knowledge as to the role of individual values in predicting risky sexual activity.
Ajzen, I., Alexandra Kozlova, Anna Kwiatkowska, Anu Realo, Borisenko, K. K., Brislin, R., European Centre for Epidemiological Monitoring of AIDS in Europe, European Centre for Epidemiological Monitoring of AIDS in Europe, Fukuyama, F., George Nizharadze, Goodwin, R., Joint United Nations Programme on HIV/AIDS., Joint United Nations Programme on HIV/AIDS., Joint United Nations Programme on HIV/AIDS., Joint United Nations Programme on HIV/AIDS., Kachkachishivili, Y., Kalichman, S. C., Lan Anh Nguyen Luu, McCormick, N., Nascimento-Schulze, C., Realo, A., Rhodes, T., Robin Goodwin, Rokeach, M., Schwartz, S. H., Towianska, A., Wellings, K., Werner, O., World Health Organization, Zuckerman, M.   +29 more
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Clique topology reveals intrinsic geometric structure in neural correlations [PDF]

, 2015
Detecting meaningful structure in neural activity and connectivity data is challenging in the presence of hidden nonlinearities, where traditional eigenvalue-based methods may be misleading. We introduce a novel approach to matrix analysis, called clique
Curto, Carina, Giusti, Chad, Itskov, Vladimir, Pastalkova, Eva   +3 more
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Separation of Oligosaccharides from Lotus Seeds via Medium-pressure Liquid Chromatography Coupled with ELSD and DAD [PDF]

, 2017
peer-reviewedLotus seeds were identified by the Ministry of Public Health of China as both food and medicine. One general function of lotus seeds is to improve intestinal health.
AD Orozco-Cortes, BA Olsen, C Huang, D Feria-Gervasio, D García-Gómez, E Borch, FLY Fong, G Yen, H Kaplan, H Wang, J Li, J Valette, J Yang, Jh Wang, K Nimptsch, M Björklund, M Björklund, M Fernández, M Lv, MT Machado, O Bañuelos, P Hemström, P Weber, PK Mukherjee, R Tabasco, S Challal, S Gusakova, S Wu, T Ignatova, T Ikegami, TCMV Do, W Oleszek, W Zong, X Lu, X Lu, Y García-Curbelo, Y Zhang, YF Zheng, Z Guo, Z Yang   +39 more
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