Results 21 to 30 of about 17,696,992 (301)

A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity

Molecules, 2023
To investigate and compare the pharmacokinetic profile and anti-cancer activity of fluorinated and iodinated photosensitizers (PSs), the 3-(1′-(o-fluorobenzyloxy)ethyl pyropheophorbide and the corresponding meta-(m-) and para (p-) fluorinated analogs ...
Taur Prakash Pandurang, Joseph Cacaccio, Farukh A. Durrani, Mykhaylo Dukh, Ajyal Z. Alsaleh, Munawwar Sajjad, Francis D’Souza, Dalip Kumar, Ravindra K. Pandey   +8 more
doaj   +1 more source

Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives

Molecules, 2015
A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi.
Zhibin Li, Shaohua Chen, Shaowen Zhu, Jianjun Luo, Yaomou Zhang, Qunfang Weng   +5 more
doaj   +1 more source

Structure-activity relationships of estrogens.

Environmental Health Perspectives, 1985
The last 50 years has seen an exponential rise in the published reports about estrogen action. The model to describe the early events in the mechanism of action of estrogens via the estrogen receptor is updated in this paper to incorporate some of the recent data on the subcellular localization of the receptor.
V C, Jordan, S, Mittal, B, Gosden, R, Koch, M E, Lieberman   +4 more
openaire   +2 more sources

Synthesis and Antibacterial Evaluation of N-phenylacetamide Derivatives Containing 4-Arylthiazole Moieties

Molecules, 2020
A series of new N-phenylacetamide derivatives containing 4-arylthiazole moieties was designed and synthesized by introducing the thiazole moiety into the amide scaffold.
Hui Lu, Xia Zhou, Lei Wang, Linhong Jin
doaj   +1 more source

Design, Synthesis, and Anti-Inflammatory Activities of 12-Dehydropyxinol Derivatives

Molecules, 2023
Pyxinol skeleton is a promising framework of anti-inflammatory agents formed in the human liver from 20S-protopanaxadiol, the main active aglycone of ginsenosides. In the present study, a new series of amino acid-containing derivatives were produced from
Yunxiao Wang, Xiaoliang Mi, Yuan Du, Shuang Li, Liping Yu, Meng Gao, Xiaoyue Yang, Zhihua Song, Hui Yu, Gangqiang Yang   +9 more
doaj   +1 more source

Synthesis and leishmanicidal activity of cinnamic acid esters: structure–activity relationship [PDF]

, 2014
Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcohols. Structures of the products were elucidated by spectroscopic analysis.
Vélez, Iván D., Robledo, Sara M., Diaz-Oltra, Santiago, Cardona G, Wilson I, Paños Pérez, Julián, Cardona Galeano, Wilson Isidro, Muñoz, Diana, Otero, Elver, Carda, Miguel   +8 more
core   +1 more source

Prediction of mammalian toxicity by quantitative structure-activity relationships - aliphatic amines and anilines

, 2022
S.198-204 : Abb.,Tab.Quantitative Structure-Activity Relationships (QSARs) are derived to predict oral toxicity data of aliphatic amines and anilines for rats.
Klein, W., Jäckel, H.
core   +1 more source

Progress in the Optimization of 4(1H)-Quinolone Derivatives as Antimalarials Targeting the Erythrocytic, the Exoerythrocytic and the Transmitting Stages of the Malaria Parasite

CHIMIA, 2017
Malaria is one of the leading infectious diseases occurring mainly in tropical and subtropical areas. Although available antimalarial tools have reduced the number of fatalities, there is still an urgent need for the development of new and more ...
Fabian Brockmeyer, Roman Manetsch
doaj   +1 more source

Structure-Activity Relationships of Adrenocorticoids

Experimental Biology and Medicine, 1961
SummaryThe influence of 1,2 unsaturation, 6a-methylation, 9a-fluorination, 16a-hydroxylation, and 16a,17a-ketalization alone and in combination on glycogenic and thymolytic activity has been simultaneously assessed in immature adrenalectomized rats. Good agreement between glycogenic and thymolytic relative potencies was observed.
I, RINGLER, S, MAUER, E, HEYDER
openaire   +2 more sources

Structure Features of Peptide-Type SARS-CoV Main Protease Inhibitors: Quantitative Structure Activity Relationship Study [PDF]

, 2020
In the present work, an extensive QSAR (Quantitative Structure Activity Relationships) analysis of a series of peptide-type SARS-CoV main protease (MPro) inhibitors following the OECD guidelines has been accomplished.
Vesna, Rastija, Meghshyam K., Patil, Ajaykumar, Gandhi, Vijay, Masand   +3 more
core   +1 more source