Results 21 to 30 of about 976,396 (264)

Improvement of the Oxidative Stability of Rosehip, Hemp, and Passion Fruit Oils by the Addition of Monocyclic Phenols as Antioxidants

Antioxidants
Caffeic, syringic, and protocatechuic acids are phenolic acids with important antioxidant activity. In this work we studied how the oxidative stability of rosehip, hemp, and passion fruit oils improves with the addition of these antioxidant acids.
Gloria Castellano, Irene Sarrión, Carmen Fagoaga, Ricardo M. Giménez-Núñez, Enrique Gómez-Gómez, Francisco Torrens   +5 more
doaj   +1 more source

Pyrimidine: a review on anticancer activity with key emphasis on SAR

Future Journal of Pharmaceutical Sciences, 2021
Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra, Tanya Prasad, Tripti Sharma   +2 more
doaj   +1 more source

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP

Drug Design, Development and Therapy, 2022
Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian ...
Wang L
doaj  

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop.
Ming Bian, Qian-qian Ma, Yun Wu, Huan-huan Du, Gong Guo-hua   +4 more
doaj   +1 more source

Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

Molecules, 2021
Harringtonolide (HO), a natural product isolated from Cephalotaxus harringtonia, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives ...
Xiutao Wu, Lijie Gong, Chen Chen, Ye Tao, Wuxi Zhou, Lingyi Kong, Jianguang Luo   +6 more
doaj   +1 more source

Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex

Journal of Future Foods
Glycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities.
Yu Zhong, Jiangxiong Zhu, Bifen Zhu, Hao Yin, Danfeng Wang, Yun Deng, Minyan Zhang, Chunrong Zhang   +7 more
doaj   +1 more source

Synthesis, antimicrobial screening and structure–activity relationship of novel pyrimidines and their thioethers

Bulletin of Faculty of Pharmacy Cairo University, 2014
In the present study, a series of novel pyrimidines (1) and their thioethers (2–5) were synthesized. Structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR mass spectral data and elemental analysis.
Chetan M. Bhalgat, B. Ramesh
doaj   +1 more source

Flavonoids as inhibitors of human neutrophil elastase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells.
Katarzyna Jakimiuk, Jakub Gesek, Atanas G. Atanasov, Michał Tomczyk   +3 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Research Progress on Structure, Activity and Structure-Activity Relationship of Sea Cucumber Polysaccharides [PDF]

Shipin Kexue
The sea cucumber is an invertebrate with significant economic value and is extensively consumed as a tonic food in Asian countries due to its high nutritional value.
SHU Zhiqiang, LIU Fang, JING Yuexin, JIAO Chunna, JI Yizhi, WANG Maojian, WANG Gongming, ZHANG Jian
doaj   +1 more source