Results 191 to 200 of about 3,704,653 (352)

Structure-Activity Relationship Study on Soticlestat Derivatives for the Discovery of CYP46A1 (CH24H) Inhibitors. [PDF]

Molecules
Hu X, Huang W, Lin X, Zhang H, Huang Y, Wu J, Zhao G.   +6 more
europepmc   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Relationships between the structure of organophosphorus compounds and their activity as acetylcholinesterase inhibitors.

, 1971
Fukuto Tr
openalex   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Harnessing carlina oxide scaffold for the management of vector-borne diseases: synthesis and structure-activity relationship. [PDF]

RSC Med Chem
Spinozzi E, Piergentili A, Ferrati M, Baldassarri C, Trebaiocchi G, Rossi P, Araniti F, Zambelli A, Cappellacci L, Zeppa L, Giangrossi M, Palmieri A, Pavela R, Maggi F, Petrelli R.   +14 more
europepmc   +1 more source

Synthetic studies on mitotic kinesin Eg5 inhibitors: Synthesis and structure–activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives

, 2014
Junichiro Yamamoto, Nobuyoshi Amishiro, Kazuhiko Kato, Yoshihisa Ohta, Yoji Ino, Mitsuharu Araki, Tetsuya Tsujita, Seiho Okamoto, Takeshi Takahashi, Hideaki Kusaka, Shiro Akinaga, Yoshinori Yamashita, Ryuichiro Nakai, Chikara Murakata   +13 more
openalex   +1 more source

On the Relationship between the Chemical Structure and the Cyclic AMP Phosphodiesterase Inhibitory Activity of Flavonoids as Studied by 13C NMR [PDF]

, 1989
Yohko Sakamoto, Taichi Ohmoto, Tamotsu Nikaido, Kazuo Koike, Tsuyoshi Tomimori, Yukinori Miyaichi, Yoshiaki Shirataki, Franco D. Monache, Bruno Botta, Ichirô Yokoe, MANKI KOMATSU, Shosuke Watanabe, Isao Ando   +12 more
openalex   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Identification, characterization, and structure-activity relationship of the ASIC3-selective peptide WRPRFa. [PDF]

Commun Chem
Chien C, Yang ND, Jiang V, Amagasu SM, Gilchrist JM.   +4 more
europepmc   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source