Results 171 to 180 of about 3,704,653 (352)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Structure-Activity Relationship and Crystallographic Study of New Monobactams. [PDF]

J Med Chem
Kavaš V, Contreras-Martel C, Pajk S, Knez D, Martins A, Gould TA, Roper DI, Zdovc I, Dessen A, Hrast Rambaher M, Gobec S.   +10 more
europepmc   +1 more source

1P017 The role of the mobile regions in the ATP-dependent protease activity of FtsH(Proteins-structure and structure-function relationship,Oral Presentations)

, 2007
Ryoji Suno, Natsuka Shimodate, Masakazu Shimoyama, Masasuke Yoshida   +3 more
openalex   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Discovery, Structure-Activity Relationship, and Functional Characterization of a Chromenopyrrole Series as Orthosteric Antagonists of GPR84. [PDF]

J Med Chem
Malone MA, Yin R, Li Y, Jenkins L, Guseinov AA, Marsango S, Huggett M, Huggett M, Boyle A, Morrison A, Tikhonova IG, Milligan G, Jamieson AG.   +12 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Benzotriazole in Cancer: A Systematic Review on Preclinical Evidence and Structure-Activity Relationship. [PDF]

Pharmaceuticals (Basel)
Mardale G, Prodea A, Munteanu A, Jorgovan M, Mardale S, Dumitrascu VC, Șoica C.   +6 more
europepmc   +1 more source

Structure–Activity Relationships of Voltaglue Organic Blends [PDF]

, 2020
Nigel C. S. Tan, Animesh Ghosh, Terry W. J. Steele   +2 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Structure-Activity Relationship of Antischistosomal Aryl Hydantoin (AR102). [PDF]

J Med Chem
Leas DA, Häberli C, White KL, Shackleford DM, Jones JO, Campbell M, Wu J, Kaushik D, Dong Y, Wallick AI, Charman SA, Keiser J, Davis PH, Vennerstrom JL.   +13 more
europepmc   +1 more source