Results 21 to 30 of about 5,517,395 (407)

Design, Synthesis, and Bioactivity of Novel Quinazolinone Scaffolds Containing Pyrazole Carbamide Derivatives as Antifungal Agents

Current Issues in Molecular Biology, 2022
In this study, 32 novel quinazolinone-scaffold-containing pyrazole carbamide derivatives were designed and synthesized in a search for a novel fungicide against Rhizoctonia solani.
Zhiwei Lei, Jianmei Yao, Huifang Liu, Xianjin Bai, Xingsi Gao, Qiuyuan Pan, Wen Yang   +6 more
doaj   +1 more source

QnrS1 structure-activity relationships [PDF]

Journal of Antimicrobial Chemotherapy, 2014
Loop B is important for low-level quinolone resistance conferred by Qnr proteins. The role of individual amino acids within QnrS1 loop B in quinolone resistance and gyrase protection was assessed.qnrS1 and 11 qnrS1 alleles with site-directed Ala mutations in loop B were expressed in Escherichia coli BL21(DE3) and proteins were purified by affinity ...
David C. Hooper, George A. Jacoby, María M. Tavío, María M. Tavío   +3 more
openaire   +3 more sources

Relationship Between the Structure and Immune Activity of Components From the Active Polysaccharides APS-II of Astragali Radix by Enzymolysis of Endo α-1,4-Glucanase

Frontiers in Pharmacology, 2022
Astragali Radix polysaccharides (APSs) have a wide range of biological activities. Our preliminary experiment showed that APS-Ⅱ (10 kDa) was the main immunologically active component of APSs.
Ke Li, Ke Li, Ke Li, Ke Li, Xue-qin Li, Xue-qin Li, Xue-qin Li, Guang-xin Li, Lian-jie Cui, Lian-jie Cui, Lian-jie Cui, Xue-mei Qin, Xue-mei Qin, Xue-mei Qin, Zhen-yu Li, Zhen-yu Li, Zhen-yu Li, Yu-guang Du, Yue-tao Liu, Yue-tao Liu, Yue-tao Liu, Ai-ping Li, Ai-ping Li, Ai-ping Li, Xing-yun Zhao, Xing-yun Zhao, Xing-yun Zhao, Xin-hui Fan, Xin-hui Fan, Xin-hui Fan   +29 more
doaj   +1 more source

Structure - Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis

Journal of Pure and Applied Microbiology, 2017
Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan Purkan, Sri Puji Astuti Wahyuningsih, Wiwin Retnowati, Diah Amelia, Alfain Noerdin Alimny   +4 more
doaj   +1 more source

Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2011
A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature.
Trišović Nemanja, Marković Snežana, Čomić Ljiljana, Božić Biljana, Ušćumlić Gordana, Stefanović Olgica, Božić Bojan, Obradović Ana   +7 more
doaj   +1 more source

Targeting intracellular, multi-drug resistant Staphylococcus aureus with guanidinium polymers by elucidating the structure-activity relationship [PDF]

, 2019
Intracellular persistence of bacteria represents a clinical challenge as bacteria can thrive in an environment protected from antibiotics and immune responses. Novel targeting strategies are critical in tackling antibiotic resistant infections. Synthetic
Hartlieb, Matthias, Kengmo Tchoupa, Arnaud, Kuroki, Agnès, Locock, Katherine E. S., Peltier, Raoul, Perrier, Sébastien, Unnikrishnan, Meera   +6 more
core   +1 more source

Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]

, 2020
β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik, Bossier, Peter, Cox, Eric, Han, Biao, Vanrompay, Daisy   +4 more
core   +2 more sources

Structure-activity relationships of the nikkomycins [PDF]

Journal of General Microbiology, 1991
The structure-activity relationships of different nikkomycins were studied to evaluate the structural requirements for a potent chitin synthase inhibitor. We investigated the transport of the nikkomycins via the peptide transport system of the yeast Yarrowia lipolytica and determined the kinetic parameters for nikkomycin Z uptake [Km = 24 microM, Vmax =
H. Heitsch, H.-P. Fiedler, Wilfried A. König, Hans Zähner, Heinrich Decker   +4 more
openaire   +3 more sources

Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy. [PDF]

, 2014
Membrane ion channels regulate key cellular functions and their activity is dependent on their 3D structure. Atomic force microscopy (AFM) images 3D structure of membrane channels placed on a solid substrate.
Arce, Fernando Teran, Cohen, Daniel A, Lal, Ratnesh, Patel, Nirav R, Quist, Arjan P, Ramachandran, Srinivasan   +5 more
core   +2 more sources

The relationship between redox enzyme activity and electrochemical potential—cellular and mechanistic implications from protein film electrochemistry [PDF]

, 2011
In protein film electrochemistry a redox protein of interest is studied as an electroactive film adsorbed on an electrode surface. For redox enzymes this configuration allows quantification of the relationship between catalytic activity and ...
Ackrell, Anderson, Anderson, Andrew G. Mayes, Andrew J. Gates, Angove, Armstrong, Armstrong, Armstrong, Armstrong, Armstrong, Arnoux, Bamford, Bekker, Berks, Blumberger, Blumberger, Buc, Butler, Butler, Chun Yip To, Clarke, Costa, David J. Richardson, Davis, de Vries, Dementin, Dias, Dridge, Eddowes, Ellington, Elliott, Field, Flores, Fourmond, Fourmond, Fourmond, Frangioni, Frew, Gates, Gates, Gemma L. Kemp, Georgellis, Gwyer, Hagedoorn, Hanson, Healy, Heering, Hirst, Hofmann, Hunte, Immoos, Ivanov, James Mann, Jepson, Jepson, Jeuken, Julea N. Butt, Kell, Kemp, Lin, Léger, Léger, Léger, Marritt, Marsili, Moore, Murgida, Niki, Otten, Otten, Page, Pershad, Potter, Ramirez, Richardson, Ridnour, Sears, Sears, Simons, Sophie J. Marritt, Sun, Tenderholt, Tenderholt, Thauer, Tipmanee, Wang, Westerhoff, Yeh, Zuman   +89 more
core   +1 more source