Results 41 to 50 of about 5,840,078 (380)

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity

Molecules, 2023
To investigate and compare the pharmacokinetic profile and anti-cancer activity of fluorinated and iodinated photosensitizers (PSs), the 3-(1′-(o-fluorobenzyloxy)ethyl pyropheophorbide and the corresponding meta-(m-) and para (p-) fluorinated analogs ...
Taur Prakash Pandurang, Joseph Cacaccio, Farukh A. Durrani, Mykhaylo Dukh, Ajyal Z. Alsaleh, Munawwar Sajjad, Francis D’Souza, Dalip Kumar, Ravindra K. Pandey   +8 more
doaj   +1 more source

More on Comparison Between First Geometric-Arithmetic Index and Atom-Bond Connectivity Index [PDF]

, 2015
The first geometric-arithmetic (GA) index and atom-bond connectivity (ABC) index are molecular structure descriptors which play a significant role in quantitative structure-property relationship (QSPR) and quantitative structure-activity relationship ...
Akbar Ali, Akhlaq Ahmad, Bhatti, Zahid Raza   +3 more
core   +2 more sources

Structure-activity relationship in monosaccharide-based Toll-like receptor 4 (TLR4) antagonists [PDF]

, 2018
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists formed by a glucosamine core linked to two phosphate esters and two linear carbon chains.
Airoldi, Cristina, Beyaert, Rudi, Billod, Jean-Marc, Braun, Harald, Calabrese, Valentina, Ciaramelli, Carlotta, Facchini, Fabio A, Forcella, Matilde, Fusi, Paola, Jerala, Roman, Lapenta, Fabio, Martin-Santamaria, Sonsoles, Minotti, Alberto, Palmer, Charys, Peri, Francesco, Pirianov, Grisha, Rapisarda, Silvia, Schromm, Andra B, Zaffaroni, Lenny   +18 more
core   +5 more sources

Progress in the Optimization of 4(1H)-Quinolone Derivatives as Antimalarials Targeting the Erythrocytic, the Exoerythrocytic and the Transmitting Stages of the Malaria Parasite

CHIMIA, 2017
Malaria is one of the leading infectious diseases occurring mainly in tropical and subtropical areas. Although available antimalarial tools have reduced the number of fatalities, there is still an urgent need for the development of new and more ...
Fabian Brockmeyer, Roman Manetsch
doaj   +1 more source

An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources

Molecules, 2022
Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and ...
Yong-Shuai Jing, Yun-Feng Ma, Fei-Bing Pan, Ming-Song Li, Yu-Guang Zheng, Lan-Fang Wu, Dan-Shen Zhang   +6 more
doaj   +1 more source

Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]

, 2019
A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
core   +4 more sources

Improvement of the Oxidative Stability of Rosehip, Hemp, and Passion Fruit Oils by the Addition of Monocyclic Phenols as Antioxidants

Antioxidants
Caffeic, syringic, and protocatechuic acids are phenolic acids with important antioxidant activity. In this work we studied how the oxidative stability of rosehip, hemp, and passion fruit oils improves with the addition of these antioxidant acids.
Gloria Castellano, Irene Sarrión, Carmen Fagoaga, Ricardo M. Giménez-Núñez, Enrique Gómez-Gómez, Francisco Torrens   +5 more
doaj   +1 more source

Pyrimidine: a review on anticancer activity with key emphasis on SAR

Future Journal of Pharmaceutical Sciences, 2021
Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra, Tanya Prasad, Tripti Sharma   +2 more
doaj   +1 more source

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop.
Ming Bian, Qian-qian Ma, Yun Wu, Huan-huan Du, Gong Guo-hua   +4 more
doaj   +1 more source