Results 51 to 60 of about 5,731,208 (381)

Quantitative structure-activity relationship for antimalarial activity of artemisinin [PDF]

, 2010
The increase in resistance to older drugs and the emergence of new types of infection have created an urgent need for discovery and development of new compounds with antimalarial activity.
Hasan, Mohamed Noor, Jamaludin, Rosmahaida   +1 more
core  

Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs

, 2012
By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are
Bortolotto, Carlotti, Chen, Chopra, De Luigi, Doershuk, Duivenvoorden, Dutta, Lambs, McNamara, Nelson, Nelson, Silvia, Stetler-Steveson, Tang, Thong, Wainwright, Yrjanheikki   +17 more
core   +2 more sources

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]

, 2013
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S, Hughes, Michael P, Jiang, Lin, Landau, Meytal, Leibly, David, Liu, Cong, Zhao, Minglei   +6 more
core   +1 more source

Piperazine skeleton in the structural modification of natural products: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications. Over
Run-Hui Zhang, Hong-Yan Guo, Hao Deng, Jinzi Li, Zhe-Shan Quan   +4 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Relating Anaerobic Digestion Microbial Community and Process Function [PDF]

, 2016
Anaerobic digestion (AD) involves a consortium of microorganisms that convert substrates into biogas containing methane for renewable energy. The technology has suffered from the perception of being periodically unstable due to limited understanding of ...
Bocher, Benjamin T.W., Maki, James, Venkiteshwaran, Kaushik, Zitomer, Daniel   +3 more
core   +3 more sources

Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5

Molecules, 2020
Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases. They regulate many physiological processes and play important roles in inflammation, diabetes, cancers, and neurodegeneration diseases.
Haozhen Han, Chunpu Li, Man Li, Lisheng Yang, Sen Zhao, Zhifei Wang, Hong Liu, Dongxiang Liu   +7 more
doaj   +1 more source

Between Droughts and Floods: The Seasonal Response of Freshwater Snails in Artificial Reservoirs in the Brazilian Semiarid Region

Population Ecology, EarlyView.
We investigate the seasonal dynamics of two freshwater snails, Biomphalaria straminea and Melanoides tuberculata, in artificial reservoirs of the Brazilian semiarid region. Despite regulated hydrology, B. straminea exhibited strong seasonal fluctuations associated with dry periods, while M. tuberculata maintained stable populations throughout the year,
Lucas Henrique Sousa da Silva, João Hemerson de Sousa, Adriana Josefa da Rocha, Manuella Feitosa Leal, Lucas Ariel de Sousa Aguiar, Tamaris Gimenez Pinheiro, Edson Lourenço da Silva   +6 more
wiley   +1 more source

Spectral mapping of brain functional connectivity from diffusion imaging. [PDF]

, 2018
Understanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience.
Bassett, Danielle S, Becker, Cassiano O, Grafton, Scott T, Miller, Michael B, Pappas, George J, Pequito, Sérgio, Preciado, Victor M   +6 more
core   +3 more sources

α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure–activity relationship study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used in the management of type 2 diabetes mellitus.
C. Proença, M. Freitas, D. Ribeiro, Eduardo F T Oliveira, Joana L. C. Sousa, Sara M Tomé, M. Ramos, Artur M. S. Silva, P. Fernandes, E. Fernandes   +9 more
semanticscholar   +1 more source