Results 101 to 110 of about 8,160,938 (248)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution
, 2016 Chen Zhao, Anna Marie Pyle
openalex +2 more sources
Sector Neutral Portfolios: Long Memory Motifs Persistence in Market Structure Dynamics [PDF]
, 2019 Turiel, Jeremy, Aste, Tomaso
openalex +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Probing optically driven K3C60 thin films with an ultrafast voltmeter
Structural DynamicsOptically enhanced superconductivity in K3C60 is supported by transient optical spectra, by pressure responses, and by ultrafast nonlinear transport measurements.
J. D. Adelinia +7 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Crystal structure of (rac)-methyl(2S*,2R'*,4'S*,12bR*)-2,-tert-butyl-1, 2,6,7,12,12b-hexahydro-4'-methyl-2-(5'-oxo-1',3'-dioxolane-4'-yl)indolo[ 2,3-α]-quinolizine-3-carboxylate, C25H30N2O5 [PDF]
, 1997 K. Peters +5 more
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Differential perovskite hemispherical photodetector for intelligent imaging and location tracking
Nature CommunicationsAdvanced photodetectors with intelligent functions are expected to take an important role in future technology. However, completing complex detection tasks within a limited number of pixels is still challenging.
Xiaopeng Feng +9 more
doaj +1 more source