Results 131 to 140 of about 22,404,851 (343)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Predicting the cone penetration resistance of unsaturated agricultural soils by neural network

open access: yesDiscover Soil
This study develops and evaluates an Artificial Neural Network (ANN) model for predicting cone penetration resistance (CPR) in unsaturated silt loam soils.
Md. Zainul Abedin   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Adaptive multi-mode locomotion for bipedal wheel-legged robots via sparse mixture-of-experts deep reinforcement learning

open access: yesFrontiers in Robotics and AI
The bipedal wheel-legged robot combines the high energy efficiency of wheeled movement with the terrain adaptability of legged locomotion. However, achieving a smooth transition between these two heterogeneous motion modes within a unified control ...
Pan He   +4 more
doaj   +1 more source

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