Cryo-EM reveals an ensemble of cytochrome P450 reductase conformations in solution. [PDF]
Protein SciLepesheva GI, Hargrove TY, Ren Y.
europepmc +1 more source
Three-dimensional structure of the rat intestinal wall (Mucosa and submucosa).
, 1990 Terumasa Komuro, Yoshie Hashimoto
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
NTFold: Structure-Sensing Nucleotide Attention Learning for RNA Secondary Structure Prediction. [PDF]
Sensors (Basel)Jin K, Zhang Z, Lan G, Xiao S, Yang J.
europepmc +1 more source
Fabrication of a novel micron scale Y‐structure‐based chiral metamaterial: Simulation and experimental analysis of its chiral and negative index properties in the terahertz and microwave regimes [PDF]
, 2007 Nantakan Wongkasem +6 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Impact of Spatial structure of urban agglomerations on green innovation in China. [PDF]
Sci RepDong S, Liu K.
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Hierarchical simulation approach to structure and dynamics of polymers
, 1998 Alfred Uhlherr, Doros N. Theodorou
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source