Results 301 to 310 of about 3,795,656 (358)

Isatin containing heterocycles for different biological activities: Analysis of structure activity relationship

, 2020
Isatin has been widely used in drug discovery. The ring is part of many naturally occurring compounds and is used to design compounds with diverse biological activities.
R. Nath, S. Pathania, G. Grover, M. J. Akhtar   +3 more
semanticscholar   +1 more source

Structure-Activity Relationships in Coumermycins

1972
Publisher Summary This chapter focuses on the structure–activity relationships in coumermycins. The naturally occurring coumermycins are produced in fermentation broths of several species of Streptomyces . Degradative studies at Bristol–Banyu Research Institute established the structures of coumermycins A 1 and A 2 .
J C, Godfrey, K E, Price
openaire   +2 more sources

Extraction, identification and structure-activity relationship of antioxidant peptides from sesame (Sesamum indicum L.) protein hydrolysate.

Food Research International, 2019
To elucidate the sequence, origin and structure-activity relationship of antioxidant peptides from sesame protein, sesame protein was hydrolysed by a dual-enzyme system comprised alcalase and trypsin, then this hydrolysate was fractionated by ...
Xin Lu, Lixia Zhang, Qiang Sun, Guohui Song, Jinian Huang   +4 more
semanticscholar   +1 more source

Statistical Analysis of Structure-Activity Relationships

Toxicological Sciences, 1983
The relationship between organic structure and biological activity (toxicity) is examined by statistically comparing concentration-response regression lines among structurally related compounds. Response data from acute toxicity tests are initially transformed to the logistic function while concentration data are transformed to the logarithm base 10 ...
K L, Daniels, J C, Goyert, R H, Strand, M P, Farrell   +3 more
openaire   +2 more sources

Structure–activity relationship of cationic surfactants as antimicrobial agents

, 2020
Cationic surfactants are widely used as antimicrobial agents in various fields. However, the widespread use of cationic surfactants has caused huge accumulation in environment, triggering the emergence of bacterial resistance.
Chengcheng Zhou, Yilin Wang
semanticscholar   +1 more source

Exploiting Structure–Activity Relationships in Docking

Journal of Chemical Information and Modeling, 2008
From the perspective of 2D chemical descriptors, error in docking activity predictions is separated into noise and systematic components. This error framework explains how fitting docking scores to a 2D-QSAR equation often improves accuracy as well as its logical limits.
David C. Sullivan, Eric J. Martin
openaire   +2 more sources

Pectin oligosaccharides from fruit of Actinidia arguta: Structure-activity relationship of prebiotic and antiglycation potentials.

Carbohydrate Polymers, 2019
Pectin oligosaccharides (POSs) have prebiotic and antiglycation activities in vitro, but the specific structure-activity relationship is unclear. In this study, POSs were obtained by enzymatic and ultrasound-assisted enzymatic degradation of pectin ...
Rugang Zhu, Cong Wang, Lijiao Zhang, Yu Wang, Gang Chen, Jungang Fan, Y. Jia, Fengwen Yan, Chong Ning   +8 more
semanticscholar   +1 more source

The Relationship between Structure and Activity of Taurolin

Journal of Applied Bacteriology, 1980
Taurolin [Bis(1,1‐dioxo‐perhydro‐1,2,4 thiadiazinyl‐4)methane] is an antimicrobial compound formed by the condensation of two molecules of taurine with three of formaldehyde. It has been suggested that it releases formaldehyde in contact with bacteria. Evidence from TLC, HPLC and NMR spectroscopy indicates that taurolin is mostly hydrolysed in aqueous ...
Myers, E., Allwood, M.C., Gidley, M.J., Sanders, J.K.M.   +3 more
openaire   +5 more sources

Quantitative Structure-Activity Relationship (QSAR): Modeling Approaches to Biological Applications

Encyclopedia of Bioinformatics and Computational Biology, 2019
Quantitative structure-activity relationship (QSAR) methods are important for prediction of biological effect of chemical compounds based on mathematical and statistical relations.
Swathik Clarancia Peter, J. Dhanjal, Vidhi Malik, Navaneethan Radhakrishnan, Mannu Jayakanthan, D. Sundar   +5 more
semanticscholar   +1 more source

Pyrrole: An insight into recent pharmacological advances with structure activity relationship.

European journal of medicinal chemistry, 2018
Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for the generation of library of enormous lead molecules. Owing to its vast pharmacological profile, pyrrole and its analogues have drawn much attention of the ...
Shujauddin Ahmad, O. Alam, M. Naim, M. Shaquiquzzaman, M. Alam, M. Iqbal   +5 more
semanticscholar   +1 more source