Results 91 to 100 of about 7,102,543 (272)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Thermal Sensitive Shape Memory Behavior of Epoxy Composites Reinforced with Silicon Carbide Whiskers

open access: yesApplied Sciences, 2017
A novel shape memory polymer composite was fabricated by introducing various amounts of silicon carbide whiskers (SiCws) into a shape memory epoxy.
Yongkun Wang   +3 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Analysis on Trap Panel Structure for Aircraft Outer Wing-fuselage Connection

open access: yesHangkong gongcheng jinzhan, 2019
The trap panel structure can give full play to the role of dispersing load and reducing regional stress level. The force transfer characteristics of different types of trap panel structures are analyzed, and the main design points of trap panel ...
Tang Ping, Liu Ting, Zhang Mingxing
doaj   +1 more source

Transit Thermal Control Design for Galileo Entry Probe for Planet Jupiter [PDF]

open access: yes, 1982
A totally passive design was completed for the thermal control of the Galileo entry probe during its transit to the planet Jupiter. The design utilizes radio isotope heater units, multilayer insulation blankets and a thermal radiator in conjunction with ...
Haverly, George C., Pitts, William
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Fuzzy Neural Network Q-Learning Method for Model Disturbance Change: A Deployable Antenna Panel Application

open access: yesInternational Journal of Aerospace Engineering, 2019
This paper addresses the disturbance change control problem with an active deformation adjustment mechanism on a 5-meter deployable antenna panel. A fuzzy neural network Q-learning control (FNNQL) strategy is proposed in this paper for the disturbance ...
Zhiyong Liu   +3 more
doaj   +1 more source

Novel Worst-Case Surface Accuracy Evaluation Method and Its Application in Reflector Antenna Structure Design

open access: yesIEEE Access, 2019
In order to ensure the electrical performance of the reflector antenna, the surface accuracy constraint need to be satisfied during the structure design.
Shufei Feng   +4 more
doaj   +1 more source

Sparse experimental design : an effective an efficient way discovering better genetic algorithm structures [PDF]

open access: yes, 2001
The focus of this paper is the demonstration that sparse experimental design is a useful strategy for developing Genetic Algorithms. It is increasingly apparent from a number of reports and papers within a variety of different problem domains that the ...
Braiden, P. M.   +4 more
core  

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