Results 81 to 90 of about 311,932 (330)

UV-Photolithography Fabrication of Poly-Ethylene Glycol Hydrogels Encapsulated with Hepatocytes [PDF]

, 2006
The development of biomanufacturing technologies particularly, layered manufacturing has advanced cell encapsulation processes in an effort to mimic the cellular microenvironment for invitro studies.
Chang, R., Starly, B., Sun, W.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Current and Future Perspectives on the Structural Identification of Small Molecules in Biological Systems

Metabolites, 2016
Although significant advances have been made in recent years, the structural elucidation of small molecules continues to remain a challenging issue for metabolite profiling.
Daniel A. Dias, Oliver A.H. Jones, David J. Beale, Berin A. Boughton, Devin Benheim, Konstantinos A. Kouremenos, Jean-Luc Wolfender, David S. Wishart   +7 more
doaj   +1 more source

Local Structural Features Elucidate Crystallization of Complex Structures

ACS Nano
38 pages, 6 figures, 80 ...
Maya M. Martirossyan, Matthew Spellings, Hillary Pan, Julia Dshemuchadse   +3 more
openaire   +3 more sources

First-Principles Electronic Structure of Solid Picene

, 2009
To explore the electronic structure of the first aromatic superconductor, potassium-doped solid picene which has been recently discovered by Mitsuhashi et al with the transition temperatures $T_c=7 - 20$ K, we have obtained a first-principles electronic ...
Blöchl P. E., Csányi G., De A., Hannay N. B., Hebard A. F., Hummer K., Jerome D., Kawasaki N., Koma A., Marzari N., Minakata T., Okamoto H., Palstra T. T. M., Tanigaki K., Taniguchi H., Troullier N., Valle R. G. D., Weller T. E., Yamauchi J.   +18 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Isolation of two steroidal saponins with antileishmanial activity from Allium giganteum L.

Research in Pharmaceutical Sciences
Background and purpose: Alliums are rich sources of steroidal saponins, flavonoids, and sulphoric compounds of which steroidal saponins have recently received more attention due to their important pharmacological activities. Allium giganteum (giant onion)
Farnaz Chaparian, Zeinab Delazar, Masoud Sadeghi Dinani   +2 more
doaj   +1 more source

Pentacoordination at antimony via endocyclic and exocyclic intramolecular interactions in dibenzostibocine diorganodithiophosphates [{D(C6H4S)2}Sb{S2P(OR)2}] (D=O, S)

Main Group Metal Chemistry, 2013
Treatment of [{D(C6H4S)2}SbCl] (D=O, 1; D=S, 2) with MS2P(OR)2 afforded the stable dibenzostibocine dithiophosphate compounds [{D(C6H4S)2}Sb{S2P(OR)2}] with D=O, R=1,2-C6H4 (3); for D=S, R=1,2-C6H4 (4), Et (5), nPr (6), iPr (7), and Ph (8). The compounds
Alvarado-Rodríguez José G., González-Montiel Simplicio, Andrade-López Noemí   +2 more
doaj   +1 more source

The NMR2 Method to Determine Rapidly the Structure of the Binding Pocket of a Protein–Ligand Complex with High Accuracy

Magnetochemistry, 2018
Structural characterization of complexes is crucial for a better understanding of biological processes and structure-based drug design. However, many protein–ligand structures are not solvable by X-ray crystallography, for example those with low affinity
Marielle Aulikki Wälti, Julien Orts
doaj   +1 more source