Results 41 to 50 of about 41,018 (241)

Increased NMDA receptor inhibition at an increased Sevoflurane MAC

BMC Anesthesiology, 2012
Background Sevoflurane potently enhances glycine receptor currents and more modestly decreases NMDA receptor currents, each of which may contribute to immobility.
Brosnan Robert J, Thiesen Roberto
doaj   +1 more source

Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats

Frontiers in Systems Neuroscience, 2020
A mid-thoracic spinal cord injury (SCI) severely impairs activation of the lower limb sensorimotor spinal networks, leading to paralysis. Various neuromodulatory techniques including electrical and pharmacological activation of the spinal networks have ...
Raymond Chia, Raymond Chia, Hui Zhong, Bryce Vissel, Bryce Vissel, V. Reggie Edgerton, V. Reggie Edgerton, V. Reggie Edgerton, V. Reggie Edgerton, V. Reggie Edgerton, V. Reggie Edgerton, Parag Gad, Parag Gad   +12 more
doaj   +1 more source

Effect of intrathecal glycine and related amino acids on the allodynia and hyperalgesic action of strychnine or bicuculline in mice [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundThe intrathecal (IT) administration of glycine or GABAA receptor antagonist result in a touch evoked allodynia through disinhibition in the spinal cord.
Eui Sung Lim, Il Ok Lee
doaj   +1 more source

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

Magnetic Resonance in Chemistry, EarlyView.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath, Juan Carlos Fuentes Monteverde, Swaraj Pathak, Christian Griesinger   +3 more
wiley   +1 more source

Hazards to golden-mantled ground squirrels and associated secondary hazard potential from strychnine baiting for forest pocket gophers [PDF]

, 1984
Radio telemetry and capture-recapture techniques were used to evaluate the hazards to golden-mantled ground squirrels (Spermophilus lateralis) from hand baiting with 0.5% strychnine-treated oats for western pocket gophers (Thomomys mazama) on conifer ...
Anthony, R. Michael, Evans, James, Lindsey, Gerald D.   +2 more
core  

Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes

Frontiers in Molecular Biosciences, 2018
The 25 human bitter taste receptors (hT2Rs) recognize thousands of structurally and chemically diverse bitter substances. The binding modes of human bitter taste receptors hT2R10 and hT2R46, which are responsible for strychnine recognition, were ...
Ava Yuan Xue, Ava Yuan Xue, Antonella Di Pizio, Antonella Di Pizio, Anat Levit, Tali Yarnitzky, Tali Yarnitzky, Osnat Penn, Tal Pupko, Masha Y. Niv, Masha Y. Niv   +10 more
doaj   +1 more source

Simultaneous Detection of GABA and Glycine Using MEGA‐PRESS With TE Optimization at 3T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To achieve the simultaneous acquisition of gamma‐aminobutyric acid (GABA) and glycine (Gly) using a MEGA‐PRESS sequence with an optimized TE at 3T. Methods MEGA‐PRESS simulations were performed at TEs 60‐88 ms to determine the optimal TE for Gly detection with minimal myo‐Inositol (mI) overlap and maximal GABA detection sensitivity ...
Justin R. Singer, Kimberly L. Chan
wiley   +1 more source

Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes

Marine Drugs, 2011
Fish detect extremely low levels of marine toxins tetrodotoxin (TTX) and saxitoxin (STX) via the specialized gustatory receptor(s). Physiological and pharmacological studies show that receptor(s) for TTX and STX are distinct from those which detect ...
Toshiaki J. Hara
doaj   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Effects of ethylenediamine – a putative GABA-releasing agent – on rat hippocampal slices and neocortical activity in vivo [PDF]

, 2010
The simple diamine diaminoethane (ethylenediamine, EDA) has been shown to activate GABA receptors in the central and peripheral nervous systems, partly by a direct action and partly by releasing endogenous GABA.
Addae, J.I., Lui, C., Stone, T.W.
core   +1 more source