Results 61 to 70 of about 120,860 (234)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Engaging our Students in the Learning Process: Some Points for Consideration

International Journal for the Scholarship of Teaching and Learning, 2008
Excerpt:Over the past few years there has been considerable emphasis on the concept of ‘student engagement’. This at first sight is somewhat peculiar given that the mission of universities is surely to engage students in learning through providing the ...
Lorraine Stefani
doaj   +1 more source

Critiques of Student Engagement

Higher Education Policy, 2017
Student engagement initiatives at the national, institutional and classroom level have emerged against a backdrop of rising participation rates and the marketisation of higher education. This context has informed the development of a literature that is heavily influenced by cause-effect framing and a focus on effectiveness.
Macfarlane, Bruce, Tomlinson, Michael
openaire   +6 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

School engagement and student burnout among medical and health science students in Saudi Arabia-cross-sectional study

Scientific Reports
School engagement and burnout are contributing factors influencing academic student performance. Student burnout is a serious concern in higher education, where it can result in poor mental and physical health and school dropout.
Amal Mohammed Qasem Surrati, Walaa Abdullah Mumena, Shymaa Abdullah Damfo, Albraa Badr Alolayan, Marwan M. A. Aljohani, Abdulaziz Mofdy Almarwani, Hanaa Mohammed Surrati   +6 more
doaj   +1 more source

Teaching matters: Developing as a Teacher/Librarian [Column]: Rules of Engagement: Best Practices for Connecting with Students

Communications in Information Literacy, 2010
This column focuses on the conceptual and practical aspects of teaching information literacy. Column co-editor Patrick Ragains and I write about trends and issues that have come to our attention, but we also solicit contributions to this space.
Janelle M. Zauha
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Effect of teacher–student relationship on academic engagement: the mediating roles of perceived social support and academic pressure

Frontiers in Psychology
Although previous research has established that a strong teacher–student relationship can enhance students’ academic engagement, the mechanisms underlying this effect remain less explored.
Xiangliang Liu
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source