Results 61 to 70 of about 124,372 (233)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Engaging our Students in the Learning Process: Some Points for Consideration

open access: yesInternational Journal for the Scholarship of Teaching and Learning, 2008
Excerpt:Over the past few years there has been considerable emphasis on the concept of ‘student engagement’. This at first sight is somewhat peculiar given that the mission of universities is surely to engage students in learning through providing the ...
Lorraine Stefani
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Teaching matters: Developing as a Teacher/Librarian [Column]: Rules of Engagement: Best Practices for Connecting with Students

open access: yesCommunications in Information Literacy, 2010
This column focuses on the conceptual and practical aspects of teaching information literacy. Column co-editor Patrick Ragains and I write about trends and issues that have come to our attention, but we also solicit contributions to this space.
Janelle M. Zauha
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The relationship between student engagement and dropout risk in early adolescence

open access: yesInternational Journal of Educational Research Open
One of the most reliable predictors of school effectiveness is student engagement, which is not only related to students’ current achievement but also long-term outcomes.
Lilla Szabó   +2 more
doaj   +1 more source

Critiques of Student Engagement

open access: yesHigher Education Policy, 2017
Student engagement initiatives at the national, institutional and classroom level have emerged against a backdrop of rising participation rates and the marketisation of higher education. This context has informed the development of a literature that is heavily influenced by cause-effect framing and a focus on effectiveness.
Macfarlane, Bruce, Tomlinson, Michael
openaire   +6 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

School engagement and student burnout among medical and health science students in Saudi Arabia-cross-sectional study

open access: yesScientific Reports
School engagement and burnout are contributing factors influencing academic student performance. Student burnout is a serious concern in higher education, where it can result in poor mental and physical health and school dropout.
Amal Mohammed Qasem Surrati   +6 more
doaj   +1 more source

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