Results 251 to 260 of about 13,206,153 (312)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Does viewing pre-lab dissection summary videos correlate with student performance outcomes in medical gross anatomy? [PDF]

Anat Sci Educ
Kruskie ME, Wisner RL, Byram JN, Vargo-Gogola T, Deane AS.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Enhancing e-learning through AI: advanced techniques for optimizing student performance. [PDF]

PeerJ Comput Sci
Mahafdah R, Bouallegue S, Bouallegue R.
europepmc   +1 more source

An Analysis of Obstetrics and Gynecology Medical Student Performance Evaluation Clerkship Narratives: Insights From the PRIME+ Framework. [PDF]

J Grad Med Educ
Shui ML, Armstrong W, Altendahl M, Shanks A, Sims SM, Ratan RB, Saab SS.   +6 more
europepmc   +1 more source

Experimental effects of multi-dance sport training on student performance: a dual analysis of physical fitness and aesthetic skill development. [PDF]

Front Psychol
Yu L, Gu Y, Chen L, Wan J.
europepmc   +1 more source

A comparative study of medical student performance and satisfaction in an in-person vs online chronic pain certificate program. [PDF]

Tunis Med
Rouached L, Bouden S, Ben Tekaya A, Fazaa A, Ben Rhouma H, Ben Salem T, Mokrani A, Khalbous S, Charfi R, Tekaya R.   +9 more
europepmc   +1 more source

GOAT: a novel global-local optimized graph transformer framework for predicting student performance in collaborative learning. [PDF]

Sci Rep
Peng T, Yue Q, Liang Y, Ren J, Luo J, Yuan H, Wu W.   +6 more
europepmc   +1 more source

RETRACTED: TGEL-transformer: Fusing educational theories with deep learning for interpretable student performance prediction.

PLoS One
Gong Y, Wang F, Zhang Y, Geng J.
europepmc   +1 more source