Results 111 to 120 of about 2,203,622 (278)

Specialty preferences among Nigerian medical students: a cross sectional study

open access: yesBMC Medical Education
Introduction Specialty preferences among medical students significantly influence healthcare workforce distribution and equity. Nigeria, with its low physician-to-patient ratio, faces critical challenges in addressing healthcare demands.
Tobi Olajide   +42 more
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Characterization of the student component in the door-to-door active screening related to COVID-19

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020
Background: the student component in the door-to-door active screening related to COVID-19 is essential for the early detection of positive cases and risk groups.Objective: to characterize the student component in the door-to-door active screening ...
Vladimir Molina-Raad
doaj  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Sexual and Reproductive Health in Rwanda [PDF]

open access: yes, 2016
KEY MESSAGES Empowerment (women, youth, communities) Inclusion (age + gender) Prevention/Early Detection PROGRAM RECOMMENDATIONS Partner with Rwandan medical students to improve program delivery Communicate monthly with local leaders Partner with ...
Zhang, Emily
core   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Awareness and attitude towards fertility and parenthood: a comparative study among medical students in Saudi Arabia

open access: yesKhyber Medical University Journal
OBJECTIVE:  To compare the awareness, attitudes towards fertility, and intentions for parenthood between preclinical and clinical medical students. METHODS:  An online cross-sectional study was conducted among preclinical and clinical medical students ...
Fehmida Tehsin   +2 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy