Results 121 to 130 of about 69,193,478 (249)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Identifying Confidence Levels and Instructional Strategies of High School Agriculture Education Teachers When Working with Students with Special Needs.

open access: yes, 2009
In Agricultural Education, teachers are experiencing increased student diversity within their classrooms. The purpose of this study was to identify the confidence levels of high school agriculture teachers and to determine what strategies they are using ...
Stair, Kristin Shawn
core  

The Model for Identifying the Dimensions and Components of AI-Based Tailored Physical Education for Students with Special Needs: A Meta-Synthesis Approach

open access: yesتحلیل مدارها، داده ها و سامانه ها
The present study was conducted with the aim of identifying the dimensions and components of artificial intelligence-based physical education adapted for students with special needs.
Homeira Kaveh   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Professionalism of Islamic education teachers in teaching to special needs students [PDF]

open access: yes
Teacher professionalism in special education plays a crucial role in ensuring the effectiveness of instruction for special needs students. In the context of Islamic education, the challenge of meeting the learning needs of special needs students requires
Mohd Fakhruddin, Fathiyah   +1 more
core   +1 more source

Academic Advisors’ Experiences and Needs Working with Students with Disabilities: A Case of Chiang Mai University

open access: yesInternational Journal of Child Development and Mental Health, 2019
The purposes of this research study were to examine 1) advisors’ experiences and needs working with students with disabilities, including awareness of disability issues, individuals’ comfort levels when dealing with various types of disabilities ...
Ratchaneekorn Tongsookdee
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Beyond development: applying the human development paradigm to identifying children with special needs and disabilities [PDF]

open access: yes, 2013
This paper explores two aspects of development in relation to children’s learning: cognitive developmental theories and the human development paradigm. In doing so the aim of the paper is to put forward first a critique of how developmental theories have
Devecchi, Cristina
core  

Home - About - Disclaimer - Privacy