Results 31 to 40 of about 1,547,013 (304)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
And, 2017 House Garibaldi was born by the legend which tells about Garibaldi refugees for a short time in the secret attic of the house. Situated into the Catania historical centre, during the 20 years of Fascism, was the Chamber of Commerce, dance school ...
Studio Gum
doaj
Images du Travail, Travail des ImagesThis article presents the results of a quantitative analysis of images showing employees at work featuring on the websites of quebec-based large video game studios (more than 100 employees), in the light of statistics on the socio-demographic profiles ...
Gabrielle Trépanier-Jobin +1 more
doaj +1 more source
The Audience of The City at Dawn Performance [PDF]
Художественная культураThe phenomenon of the Moscow State Theatre Studio under the direction of Alexei Arbuzov and Valentin Pluchek, which in February 1941 produced the play The City at Dawn about the construction of Komsomolsk-on-Amur, can be viewed from different angles. One
Mashukova Аlexandra V.
doaj +1 more source
Opening New Doors: Hands-On Participation Brings A New Audience to the Clay Studio [PDF]
, 2015 This case study examines how The Clay Studio, a ceramic-arts studio, gallery and shop in Philadelphia, attracted younger audiences to its workshops and exhibits.
Bob Harlow, Tricia Heywood
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
And, 2017 The house is located in Porto Palo (Menfi), a small sea village on the southwest coast of Sicily, where the houses are placed randomly. Still, they suggest some "consolidated order" on the whole.
Vid'A Studio
doaj
Dissemination of innovative teaching and learning practice : the global studio [PDF]
, 2009 This project aims to disseminate teaching and learning resources from an innovative programme called the Global Studio to the ADM-HEA community. The area of innovation developed in the Global Studio was to link student teams across the globe in ‘designer’
Bohemia, Erik, Harman, Kerry
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source