Results 51 to 60 of about 1,025,164 (345)

Hollywood studio filmmaking in the age of Netflix: a tale of two institutional logics

, 2020
Online streaming services are challenging long-standing decision-making processes in the traditional motion picture industry, thus placing Hollywood major studios at a crossroads.
Allègre L. Hadida, J. Lampel, W. Walls, Amit M. Joshi   +3 more
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Titien. Actualité des études

Perspective, 2008
Titian is an inescapable figure in the history of Venetian painting, casting his shadow over the majority of contemporary artists. Veronese, Tintoretto, and Lotto are often judged in relation to his manierà, and their stylistic characteristics are ...
Guillaume Cassegrain
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Casa Garibaldi

And, 2017
House Garibaldi was born by the legend which tells about Garibaldi refugees for a short time in the secret attic of the house. Situated into the Catania historical centre, during the 20 years of Fascism, was the Chamber of Commerce, dance school ...
Studio Gum
doaj  

Evaluation of Different Housing Typologies with a Design Pedagogy

Architecture
Design studios generally concentrate on some critical concerns of urban life to overcome, and housing is one of those. Rapid development and advanced technology increase the need for and problems with housing. Such concerns should be addressed in theory,
Yalcin Yildirim, Elif Altas Cakil, Merve Ersoy   +2 more
doaj   +1 more source

DESY, fates of faber's houses and ateliers

piano b, 2020
This paper presents an interdisciplinary research project related to the Design Department of the Milan Polytechnic, aimed to identifying experimental valorisation strategies for a specific typology of spaces, the faber's houses / ateliers. If so D.E.SY (
Anna Mazzanti
doaj   +1 more source

Together but Apart: Creating and Supporting Online Learning Communities in an Era of Distributed Studio Education

International Journal of Art & Design Education, 2020
It would seem that technological campuses of tomorrow have manifested in 2020 as an essential spontaneous response to a world event. This article examines the current crisis in physical art and design studio learning in higher education as a consequence ...
Lorraine Marshalsey, Madeleine Sclater
semanticscholar   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source