Results 41 to 50 of about 636,777 (309)

Sherrill's Studio

open access: yes, 2020
This photograph showing Sherrill's Studio on Depot Street is part of the Sherrill Studio Collection. George Dexter Sherrill (1879–1931) opened the first photography studio in Haywood County on Depot Street in downtown Waynesville in 1902.
Sherrill's Photography Studio;
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang   +10 more
wiley   +1 more source

Oltre il mare

open access: yesAnd, 2017
The house is located in Porto Palo (Menfi), a small sea village on the southwest coast of Sicily, where the houses are placed randomly. Still, they suggest some "consolidated order" on the whole.
Vid'A Studio
doaj  

Face cachée

open access: yesPhotographica
Studio albums are a major, albeit very rare source for understanding the workings of professional photo studios in the nineteenth century. From their emergence in the mid-1850s, they became central instruments of studio activity and customer relations ...
Olga Lemagnen, Flora Triebel
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

The sources of esthetic principles of producing of Y.A. Zavadsky

open access: yesНеофилология, 2015
Yury Aleksandrovich Zavadsky – one of the greatest directors of XX century. The uniqueness of his directing esthetic principles is that the sources are the creative works of many outstanding Masters of directing and theatre pedagogy: E.B. Vakhtangov, K.S.
Valentina Aleksandrovna SAZONOVA
doaj   +2 more sources

La mujer en el espacio pintado: de la Edad Moderna a la Contemporánea / The Woman in the Painted Space: From the Modern to the Contemporary Age

open access: yesAsparkía, 2010
RESUMEN: La pintura es una fuente esencial para la historia y un elemento revelador para la investigación sobre el papel de la mujer en la sociedad a lo largo de la historia.
Rafael Matas Fernandez   +1 more
doaj  

DESY, fates of faber's houses and ateliers

open access: yespiano b, 2020
This paper presents an interdisciplinary research project related to the Design Department of the Milan Polytechnic, aimed to identifying experimental valorisation strategies for a specific typology of spaces, the faber's houses / ateliers. If so D.E.SY (
Anna Mazzanti
doaj   +1 more source

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