Results 231 to 240 of about 48,598,601 (312)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The role of loneliness in smartphone addiction levels of adolescent online game players. [PDF]

Front Psychol
Birkok MC, Isik O, Talaghir LG, Manolache GM.   +3 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Sexual minority (LGBQ+) women's experiences of accessing addiction services: a qualitative study. [PDF]

Front Public Health
Hillyard M, Hakim J, Drummond C, Rimes K, Roberts E.   +4 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Internet addiction as a predictor of emotional eating in young adults: the incremental role of psychological variables. [PDF]

Front Psychol
Öngün Yılmaz H, Günal AM, Yılmaz S.
europepmc   +1 more source

Exploring the relationships between electronic blackmail awareness, smartphone addiction, and escapism among nursing students: a structural equation modeling approach. [PDF]

BMC Nurs
Baraka SIM, Mohamed SMS, Baraka NIM.
europepmc   +1 more source

The Relationship Between Ostracism and Mental Health Issues Among College Students: The Chain Mediating Role of Rumination and Smartphone Addiction. [PDF]

Behav Sci (Basel)
Zhang C, Wang Z, Hua W, Lin J, Liu D.
europepmc   +1 more source

Progressing from Simple to Multidimensional Models Towards a Biopsychosocial Framework of Addiction. [PDF]

Curr Addict Rep
Regier PS.
europepmc   +1 more source

Influencing factors of smartphone addiction in the era of artificial intelligence: based on the perspective of home-school. [PDF]

Front Psychol
Fei J, Zhang Y.
europepmc   +1 more source