Results 121 to 130 of about 35,019,213 (291)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Studyholism as a New Potential OCD-Related Disorder: What Evidence Have We Gathered until Now? A Narrative Review

Behavioral Sciences
In 2017, Loscalzo and Giannini introduced the new potential clinical condition of studyholism (or obsession toward study) and a comprehensive model including its possible antecedents and outcomes.
Yura Loscalzo
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Welcome to the Volume [PDF]

, 2017
Welcome to the fifth volume of the International Journal of Research on Service-Learning and Community Engagement (IJRSLCE), the annual, online, peer-reviewed publication of the International Association for Research on Service-Learning and Community ...
Richard, Dan, Perry, Lane
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Design-Based Learning and Students’ Study Engagement and Design Thinking Competence: A Study Based on the Job Demands–Resources Theory

Education Sciences
Despite many design-based learning (DBL) studies, longitudinal evidence on how course demands and resources shape design thinking competence (DTC) via study engagement remains scarce.
Zhaodi Li, Mike Joy, Dan Li, Jirarat Sitthiworachart   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Use of Multiple Methods of Engagement: A Case Study of Foreign & Colonial Investments [PDF]

The central aim of the thesis is to examine the use of multiple methods in institutional investors‟ engagement in the UK. In pursuit of that aim, the thesis seeks to examine institutional investors‟ engagement through the agency theory framework ...
Isukul, Araniyar
core  

Impact of the COVID-19 Pandemic on a Clinical Trial: A Quantitative Report on Study Engagement and Strategies. [PDF]

Pediatr Phys Ther, 2023
Brown SE, Miller M, Darring J, Inamdar K, Salgaonkar A, Burnsed JC, Stevenson RD, Shall MS, Harper AD, Hendricks-Munoz KD, Thacker LR, Hyde M, Dusing SC.   +12 more
europepmc   +1 more source

Study on Engagement Performance of Engagement Sleeve and Engagement Gear Ring of Without Synchronizer Transmission

Jixie chuandong, 2019
In order to study the engagement performance of engagement sleeve and engagement gear ring in the shifting process of without synchronous AMT transmission mounted on hybrid vehicle, improve the smoothness of gear shifting and shorten the shifting time, the theoretical analysis and the virtual prototype simulation analysis method are used to study the ...
Cui Wenxia, Zhang Ruiliang, Zhang Bo
openaire   +1 more source