Results 181 to 190 of about 34,885 (296)

Helium stunning system: Heliumbetäubung [PDF]

open access: yes
Pohůnek, Václav   +2 more
core  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

open access: yesAdvanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng   +9 more
wiley   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

open access: yesAdvanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu   +18 more
wiley   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

open access: yesAdvanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang   +10 more
wiley   +1 more source

Structural Control Over Bicontinuous Emulsions from Solvent‐Transfer Induced Phase Separation Through Nanoparticle Loading

open access: yesAdvanced Science, EarlyView.
The nanoparticle loading enables effective control over the liquid domain size in bicontinuous interfacially jammed emulsion gels (bijels) produced through solvent‐transfer induced phase separation (STrIPS). The relationship between the nanoparticle loading and domain size profiles in STrIPS bijels is resolved through confocal microscopy and explained ...
Jesse M. Steenhoff, Martin F. Haase
wiley   +1 more source

Polymer‐Grafted Cu(II) Metal–Organic Polyhedra as Scalable, Melt‐Processable Porous Materials

open access: yesAdvanced Science, EarlyView.
The use of a direct synthetic route to obtain polymer‐grafted Cu(II)‐based metal–organic polyhedra gives rise to a low‐cost and scalable cage. This material combines low‐temperature melting, achieving phase changes while preserving cage integrity, and high CO2 uptake exceeding 0.6 mmol g−1.
Alba Cortés‐Martínez   +6 more
wiley   +1 more source

Pig welfare and ethical considerations during abattoir stunning: CO2 vs. alternative methods such as argon gas

open access: yesFrontiers in Veterinary Science
Jenny L. Mace   +3 more
doaj   +1 more source

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