Results 221 to 230 of about 21,266 (292)

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, EarlyView.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Correlation of cavotricuspid isthmus dynamics with clinical parameters: insights from interventional cardiac magnetic resonance imaging. [PDF]

Eur Heart J Imaging Methods Pract
Mircea AA, de Cidrac AP, Luca A, Teres C, Pascale P, Le Bloa M, Ascione C, Domenichini G, Pagnoni M, Porretta AP, Jahnke C, Bode K, Oebel S, Lindemann F, Antiochos P, Masi A, Solana-Muñoz J, Schwitter J, Pruvot E, Paetsch I.   +19 more
europepmc   +1 more source

Development of brain damage as measured by brain impedance recordings, and changes in heart rate, and blood pressure induced by different stunning and killing methods

, 2002
Bart Savenije, E. Lambooij, M.A. Gerritzen, Jakob Korf   +3 more
openalex   +1 more source

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

Advanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong, Changyu Shang, Jinhong Gu, Huilin Tao, Xuemei Lu, Jin Hou, Zhiyong Cui, Qingsheng Qi   +7 more
wiley   +1 more source

When a Woman's Heart Fails to Contain: Takotsubo Syndrome as a Gendered Collapse of Emotional Regulation. [PDF]

Life (Basel)
Marano G, Romagnoli E, Biondi-Zoccai G, Traversi G, Mazza O, Pola R, Gaetani E, Mazza M.   +7 more
europepmc   +1 more source

Adenosine administered from the beginning of reperfusion protected myocardial stunning by activation of A1 receptors and K+ATP channels

, 2002
Martín Donato, Verónica D’Annunzio, Celina Morales, Melina Sabán, Omar Scapín, Ricardo J. Gelpi   +5 more
openalex   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, EarlyView.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

Commentary: A Comparison of the Methods of the Pre-Slaughter Stunning of Cattle in Australia-Mechanical, Electrical, and Diathermic Syncope. [PDF]

Animals (Basel)
Musk GC, Johnson CB.
europepmc   +1 more source

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

Advanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng, Željko Janićijević, Liliana R. Loureiro, Lydia Hoffmann, Poh Soo Lee, Isli Cela, Benjamin Kruppke, Alexandra Kegler, Anja Feldmann, Ielizaveta Gorodetska, Anja Madleine Markl, Anna Dubrovska, Anne Kathrin Offermann, Michael Bachmann, Larysa Baraban   +14 more
wiley   +1 more source

Resting quantitative myocardial perfusion-essential clinical coronary pathophysiology for preventing non-beneficial revascularization in cardiomyopathy. [PDF]

Eur Heart J Cardiovasc Imaging
Gould KL, Johnson NP.
europepmc   +1 more source