Results 231 to 240 of about 21,266 (292)
Advanced Science, EarlyView.Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen +15 more
wiley +1 more source
Advanced Science, EarlyView.The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu +25 more
wiley +1 more source
Relationships of corticosterone and thyroxine with mortality, mass gain, feeding and activity in Kemp's ridley sea turtles (Lepidochelys kempii) recovering from cold-stunning. [PDF]
PLoS OneHunt KE +11 more
europepmc +1 more source
cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression
Advanced Science, EarlyView.cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang +14 more
wiley +1 more source
Pilot study of online ante-mortem inspection for emergency slaughtered cattle in Denmark. [PDF]
Front Vet SciPoulsen MK, Alban L, Dresling A.
europepmc +1 more source
Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe
Advanced Science, EarlyView.The first reversible binding probe (rNTRp) is presented that selectively detects the nitroreductase enzyme's active, reduced form (red‐NTR) with a fluorescence turn‐on response. Contrary to the conventional reaction‐based probes known to date, which provide only static information on the accumulated enzyme activity at a given time, rNTRp allows ...
Sourav Sarkar +8 more
wiley +1 more source
Non-Invasive Human-Free Diagnosis Methods for Assessing Pig Welfare at Abattoirs: A Systematic Review. [PDF]
Animals (Basel)Ferreira MF, Nunes M, Vieira-Pinto M.
europepmc +1 more source
Advanced Science, EarlyView.CircLRBA is highly expressed in breast cancer (BC) and associated with poor overall survival. Zeb1 mediated circLRBA facilitates BC cell proliferation, invasion, docetaxel (DTX) resistance and inhibits the infiltration of CD8+ T cell. CircLRBA could combine with SPOP to suppress the Twist1 ubiquitination degradation and enhances PD‐L1 transcription ...
Xiaosong Wang +8 more
wiley +1 more source
Reperfusion injury in STEMI: a double-edged sword. [PDF]
Egypt Heart JThomas KS +5 more
europepmc +1 more source