Inter-society consensus on the management of acute bloody diarrhea and shiga toxin-producing Escherichia coli infection in the molecular microbiology era. [PDF]
Ardissino G +35 more
europepmc +1 more source
Study on the role of Stx2 gene in spermatogenesis of mice
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Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule [PDF]
Shiga toxin-producing Escherichia coli (STEC) causes proximal tubular defects in the kidney. However, factors altered by Shiga toxin (Stx) within the proximal tubules are yet to be shown. We determined Stx receptor Gb3 in murine and human kidneys and confirmed the receptor expression in the proximal tubules.
Fumiko Obata, Ryo Ozuru, Jun Fujii
exaly +9 more sources
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STX2 Drives Colorectal Cancer Proliferation via Upregulation of EXOSC4
Life Sciences, 2020To explore the biological function and mechanism of Syntaxin2 (STX2) in Colorectal cancer (CRC) proliferation.A series of gain- and loss-of-function analysis were conducted the to explore the biological function of STX2 in CRC proliferation in vivo and in vitro.
Zhe-Ying Zhang
exaly +3 more sources
Shiga toxin producing Escherichia coli (STEC) are bacterial pathogens involved in food-borne diseases. Shiga toxin (Stx) is the main virulence factor of STEC and is responsible for systemic complications including Hemolytic Uremic Syndrome (HUS). It has been previously demonstrated that Shiga toxin type 2 (Stx2) induces pregnancy loss in rats in early ...
Cristina Ibarra +2 more
exaly +4 more sources
STX2is a causative gene for nonobstructive azoospermia
Human Mutation, 2018STX2 encodes a sulfoglycolipid transporter. Although Stx2 nullizygosity is known to cause spermatogenic failure in mice, STX2 mutations have not been identified in humans. Here, we performed STX2 mutation analysis for 131 Japanese men clinically diagnosed with nonobstructive azoospermia.
Shigeru Nakamura +13 more
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Inhibition of Shiga Toxin 2 (Stx2) in Apple Juices and Its Resistance to Pasteurization
Journal of Food Science, 2010Abstract: In the present study, we evaluated Shiga toxin (Stx2) activity in apple juices by measuring a decrease in dehydrogenase activity of Vero cells with the microculture tetrazolium (MTT) assay. Freshly prepared juice from Red Delicious apples and Golden Delicious apples inhibited the biological activity ...
Carol E Levin +2 more
exaly +3 more sources
Detection, Enumeration and Isolation of Strains Carrying the stx2 Gene From Urban Sewage
Verotoxigenic Escherichia coli strains have been related with waterborne outbreaks. Besides 0157:H7, several serotypes of E. coli and other enterobacteria have been implicated in outbreaks and reported to carry the shiga toxin genes. Shiga toxins, stx1 and stx2, are important virulence factors of these strains.
Maite Muniesa +2 more
exaly +3 more sources
Shiga toxin Stx2 is heat-stable and not inactivated by pasteurization
International Journal of Food Microbiology, 2010Shiga toxin-producing Escherichia coli have been associated with food-borne illnesses. Pasteurization is used to inhibit microbial growth in milk, and an open question is whether milk pasteurization inactivates Shiga toxins. To answer this question we measured Shiga toxin's inhibition effect on Vero cell dehydrogenase activity and protein synthesis ...
Reuven, Rasooly, Paula M, Do
openaire +2 more sources
Engineering an Anti-Stx2 Antibody to Control Severe Infections of EHEC O157:H7
Immunology Letters, 2008Enterohaemorrhagic Escherichia coli (EHEC) O157:H7, a primary enteric pathogen, has been implicated in a wide spectrum of food/water-borne infectious diseases such as hemorrhagic colitis (HC) and hemolyticuremic syndrome (HUS). Effective treatments for EHEC O157:H7 induced disease are not available yet. Shiga-toxin 2 (Stx2) has been related to clinical
Jiang Gu, Shu Yu
exaly +3 more sources

