Results 111 to 120 of about 820,988 (298)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Prediction of subcellular location of apoptosis proteins by incorporating PsePSSM and DCCA coefficient based on LFDA dimensionality reduction

BMC Genomics, 2018
Background Apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc.
Bin Yu, Shan Li, Wenying Qiu, Minghui Wang, Junwei Du, Yusen Zhang, Xing Chen   +6 more
doaj   +1 more source

schumanlab/Subcellular-scRNAseq: Subcellular-scRNA-seq Source Code

, 2020
Source code for analysis of Subcellular scRNA-seq data generated in Perez JD. et al.
schumanlab
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

LOCATE: a mouse protein subcellular localization database

, 2006
We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set.
Kai, Chikatoshi, Davis, MJ, Kawai, J, Aturaliya, Rajith N., Teasdale, Melvena S., Teasdale, MS, Kawai, Jun, Carninci, P, Carninci, Piero, Teasdale, RD, Hayashizaki, Yoshihide, Teasdale, Rohan D., Hanson, K, Hayashizaki, Y, Zhang, Fasheng, Zhang, F, Davis, Melissa J., Fink, J. Lynn, Aturaliya, RN, Hanson, Kelly, Fink, JL, Kai, C   +21 more
core   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Subcellular Localization [PDF]

, 2006
  +5 more sources

Navigating imaging artifacts: challenges with visualizing intrinsically fluorescent antimalarials

Frontiers in Parasitology
Elucidating the target of an antiparasitic small molecule can aid in the drug development process. However, various technical challenges related to parasite biology prevent timely target identification.
Emily K. Bremers, Emily K. Bremers, David Anaguano, David Anaguano, Paul R. Carlier, Paul R. Carlier, Vasant Muralidharan, Vasant Muralidharan, Maria Belen Cassera, Maria Belen Cassera   +9 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

TRPC1: Subcellular Localization?

Journal of Biological Chemistry, 2010
Berbey et al. (1) recently reported that overexpressed TRPC1-YFP fusion protein is targeted to the sarcoplasmic reticulum of adult skeletal muscle fibers and operates as a calcium leak channel. This observation is in accordance with previous reports showing that the movement of TRPC1 to the plasma membrane is dependent on co-expression with TRPC4 or ...
Nicolas Tajeddine, Nadège Zanou, Monique Van Schoor, Jean Lebacq, Philippe Gailly   +4 more
openaire   +1 more source