Results 91 to 100 of about 4,838,802 (318)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Performance comparisons for eukaryotic protein subcellular location prediction method based on the Euk7579 dataset.

, 2013
Performance comparisons for eukaryotic protein subcellular location prediction method based on the Euk7579 dataset.
Xiaoqi Zheng (333971), Yue Zhou (71752), Changqing Li (333970), Liqi Li (333968), Lingyun Zou (333969), Bo Yu (241082), Yuan Zhang (41832)   +6 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Performance comparisons for eukaryotic protein subcellular location prediction method based on the iLoc8897 dataset.

, 2013
Performance comparisons for eukaryotic protein subcellular location prediction method based on the iLoc8897 dataset.
Xiaoqi Zheng (333971), Yue Zhou (71752), Changqing Li (333970), Liqi Li (333968), Lingyun Zou (333969), Bo Yu (241082), Yuan Zhang (41832)   +6 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Performance comparisons for human protein subcellular location prediction method based on the Hum3681 dataset.

, 2013
Performance comparisons for human protein subcellular location prediction method based on the Hum3681 dataset.
Xiaoqi Zheng (333971), Yue Zhou (71752), Changqing Li (333970), Liqi Li (333968), Lingyun Zou (333969), Bo Yu (241082), Yuan Zhang (41832)   +6 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Subcellular location of PKA controls striatal plasticity: stochastic simulations in spiny dendrites. [PDF]

PLoS Computational Biology, 2012
Dopamine release in the striatum has been implicated in various forms of reward dependent learning. Dopamine leads to production of cAMP and activation of protein kinase A (PKA), which are involved in striatal synaptic plasticity and learning.
Rodrigo F Oliveira, Rodrigo F Oliveira, Myungsook Kim, Kim T Blackwell   +3 more
doaj   +1 more source

Telomere length, telomere number and nuclear area according to the subcellular location of HBcAg.

, 2015
Telomere length, telomere number and nuclear area according to the subcellular location of HBcAg.
Suman Verma (747066), Aloysius Aravinthan (747065), Aileen Marshall (390924), Graeme J. M. Alexander (336840), Sue Penrhyn-Lowe (747067), Cinzia Scarpini (747069), Nicholas Coleman (95937), Susan E. Davies (747070), Phaedra M. Tachtatzis (747064), Marianna Mela (747068)   +9 more
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source