Results 111 to 120 of about 4,838,802 (318)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Subcellular localization and functional classification of differentially expressed proteins between C8-BR group and C8-TA groups.

, 2023
(A) The location of subcellular structures of all differentially expressed proteins. (B) The location of subcellular structures of up-regulated proteins. (C) The location of subcellular structures of down-regulated proteins. (D) The KOG classification of
Hang Sun (202258), Hongjie Dong (13861103), Huanhuan Xie (1395004), Haozhi Xu (2006134), Junmei Zhang (1890163), Guihua Zhao (5279345), Chao Xu (201376), Kun Yin (180756), Qi Wang (22418), Lisha Dai (14182248), Lixin Zhang (55947)   +10 more
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Prediction of protein submitochondria locations by hybridizing pseudo-amino acid composition with various physicochemical features of segmented sequence

BMC Bioinformatics, 2006
Background Knowing the submitochondria localization of a mitochondria protein is an important step to understand its function. We develop a method which is based on an extended version of pseudo-amino acid composition to predict the protein localization ...
Li Yanda, Du Pufeng
doaj   +1 more source

Chromosomal location and subcellular localization of ABC proteins in C. glabrata.

, 2018
(A)C. glabrata chromosomes (chrA—chrM) are displayed in circular ideogram. Black color indicates location of ABC transporter and dark maroon indicates soluble ABC proteins location.
Poonam Vishwakarma (4283983), Mahendra Varma (5693117), Mohit Kumar (399134), Garima Shahi (5693120), Nitesh Kumar Khandelwal (612028), Priya Kumari (721698), Sonam Kumari (5094149), Andrew M. Lynn (247527), Rajendra Prasad (14467), Suman Sharma (778693), Naseem A. Gaur (5693123)   +10 more
core   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

The long non-coding RNA lncRNA973 is involved in cotton response to salt stress

BMC Plant Biology, 2019
Background Long non-coding (lnc) RNAs are a class of functional RNA molecules greater than 200 nucleotides in length, and lncRNAs play important roles in various biological regulatory processes and response to the biotic and abiotic stresses.
Xiaopei Zhang, Jie Dong, Fenni Deng, Wei Wang, Yingying Cheng, Lirong Song, Mengjiao Hu, Jian Shen, Qingjiang Xu, Fafu Shen   +9 more
doaj   +1 more source

FunSecKB2: a fungal protein subcellular location knowledgebase

, 2014
FunSecKB2 is an improved and updated version of the fungal secretome and subcellular proteome, i. e. protein subcellular location, knowledgebase. The fungal protein sequence data were retrieved from UniProtKB, consisting of nearly 2 million entries with ...
John Meinken, D. Asch, Kofi A. Neizer-Ashun, Guangqiu Chang, Chester R.Cooper, Jia-Min Xiang   +5 more
semanticscholar   +1 more source

A Graphical Model to Determine the Subcellular Protein Location in Artificial Tissues.

, 2010
Location proteomics is concerned with the systematic analysis of the subcellular location of proteins. In order to perform comprehensive analysis of all protein location patterns, automated methods are needed.
Elvira Osuna-Highley (5063651), Robert Murphy (3891196), Estelle Glory-Afshar (5063654), Brian Granger (5455541)   +3 more
core   +1 more source

Subcellular Locations at which HIV-1 Assembles.

Uirusu, 2007
Virus particle formation of HIV-1 is driven by the viral structural protein Gag. In most cell types including T cells, Gag assembles into virus particles at the plasma membrane whereas, in HIV-1-infected macrophages, Gag and virus particles have been shown to accumulate in intracellular vesicles.
openaire   +3 more sources