Results 111 to 120 of about 312,772 (298)

Evaluation and Comparison of the Efficacy of Subcutaneous and Sublingual Immunotherapy for the Treatment of Allergic Asthma in Children

Children
Specific immunotherapy represents the only potentially curative treatment for allergic asthma. Allergens can be administered subcutaneously (SCIT) or sublingually (SLIT).
Vojko Berce, Maša Cugmas, Staša Čopi, Brigita Koren, Maja Tomazin, Tina Hojnik   +5 more
doaj   +1 more source

High adherence to subcutaneous immunotherapy in a real-life study from a large tertiary medical center

, 2017
Background: Studies on real-life adherence to subcutaneous allergen immunotherapy (SCIT) for respiratory allergy are scarce.
Suna Büyüköztürk, Ozseker, Ferhan, Olgac, Muge, Bayerma Khishigsuren, Issever, Halim, Khishigsuren, Bayerma, Colakoglu, Bahauddin, Aslı Gelincik, Semra Demir, Ferhan Özşeker, Bahauddin Çolakoğlu, Müge Olgaç, Buyukozturk, Suna, Demir, Semra, Halim İşsever, Gelincik, Aslı   +15 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Safety of subcutaneous immunotherapy with inhalant allergen extracts: a single-center 30-year experience from Turkey

, 2015
Context: Although subcutaneous allergen immunotherapy (SCIT) is effective in allergic rhinitis (AR) and asthma, it carries a risk of local and systemic adverse ...
Musabak, Ugur, Caliskaner, Zafer, Gulec, Mustafa, Sener, Osman, Kartal, Ozgur   +4 more
core   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

Flexible approaches in the design of subcutaneous immunotherapy protocols for Hymenoptera venom allergy

, 2006
Ann Allergy Asthma Immunol. 2006 Jul;97(1):92-7. Flexible approaches in the design of subcutaneous immunotherapy protocols for Hymenoptera venom allergy.
BERRA D, MAURO M, ROSSI F, RICCIARDI, Luisa, SPEZIA D, STANIZZI R, BURASTERO SE, RIZZINI FL, MELCHIORRE A, ALESSANDRINI AE   +9 more
core  

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Efficacy and safety of allergen-specific immunotherapy for allergic asthma: a meta-analysis comparing sublingual and subcutaneous routes across allergen types and age groups

Annals of Medicine
Purpose This meta-analysis aims to evaluate the efficacy and safety of allergen-specific immunotherapy (AIT) in treating allergic asthma.Methods A comprehensive search across PubMed, Cochrane Library, Embase and Web of Science was conducted.
Weimou Yin, Weitong Zeng, Yutong Li, Shiting Huang, Shoucheng Cen, Bangling Su, Ting Zhou, Xuejun Qin   +7 more
doaj   +1 more source

Immunotherapy in Recurrent Ovarian Cancer

Background/Objectives: It remains challenging to treat recurrent ovarian cancer effectively as traditional interventions like chemotherapy and surgery have limited long-term efficacy, highlighting an urgent need for innovative approaches.
Shaoqiong Deng, Jingjing Wang, Meng Yang, Keyao Chen, Li Sun   +4 more
core   +1 more source