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Mechanisms of Aeroallergen Immunotherapy: Subcutaneous Immunotherapy and Sublingual Immunotherapy.
Immunology and allergy clinics of North America, 2016 Allergen immunotherapy (AIT) is an effective way to treat allergic disorders, targeting the underlying mechanisms and altering the disease course by inducing a long-lasting clinical and immune tolerance to allergens. Although sublingual and subcutaneous routes are used in daily practice, many novel ways to decrease side effects and duration and ...
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Subcutaneous Immunotherapy Safety
Immunology and Allergy Clinics of North America, 2020David Bernstein, Mario Sánchez-Borges
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Safety of subcutaneous allergen immunotherapy
Allergy and Asthma Proceedings, 2022Subcutaneous allergen immunotherapy (SCIT) is a unique treatment option for managing patients with allergic rhinitis, asthma, atopic dermatitis, and stinging insect allergy. Although systemic reactions to allergen injections are rare, near-fatal, and fatal anaphylactic reactions can occur.
David I, Bernstein, Tolly G, Epstein
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Allergy and Asthma Proceedings, 2022
There are currently no biomarkers that can accurately predict clinical outcomes and segregate responders from nonresponders in allergen immunotherapy (AIT). Therefore, identifying a reliable predictive biomarker is essential to enable clinicians to tailor personalized therapy.
Tiak Ju, Tan +2 more
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There are currently no biomarkers that can accurately predict clinical outcomes and segregate responders from nonresponders in allergen immunotherapy (AIT). Therefore, identifying a reliable predictive biomarker is essential to enable clinicians to tailor personalized therapy.
Tiak Ju, Tan +2 more
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International Forum of Allergy & Rhinology, 2014
BackgroundAllergic rhinitis, asthma, and Hymenoptera sensitivity affect approximately 20%, 9%, and 0.66% to 3.3% of adults in the United States, respectively. Various environmental control measures and pharmacologic options are available for symptomatic treatment of allergic rhinitis and allergic asthma.
Ansley M, Roche, Sarah K, Wise
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BackgroundAllergic rhinitis, asthma, and Hymenoptera sensitivity affect approximately 20%, 9%, and 0.66% to 3.3% of adults in the United States, respectively. Various environmental control measures and pharmacologic options are available for symptomatic treatment of allergic rhinitis and allergic asthma.
Ansley M, Roche, Sarah K, Wise
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Advances in subcutaneous immunotherapy
Current Opinion in Otolaryngology & Head and Neck Surgery, 2014Current limitations in subcutaneous immunotherapy (SCIT) include the length of time required to achieve tolerance as well as the potential for systemic side-effects. Advances in allergen immunotherapy include targeted therapies to B-cell and T-cell pathways that can lead to more rapid desensitization and potentially the prevention of allergic disease ...
Anna J, Knisely, Stella, Lee
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Mechanisms of Subcutaneous Allergen Immunotherapy
Immunology and Allergy Clinics of North America, 2011Allergen-specific immunotherapy (SIT) is the only curative approach in the treatment of allergic diseases defined up-to-date. Peripheral T-cell tolerance to allergens, the goal of successful allergen-SIT, is the primary mechanism in healthy immune responses to allergens.
Soyer, O U, Akdis, M, Akdis, C A
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Subcutaneous Versus Sublingual Immunotherapy for Allergic Rhinitis and/or Asthma
Immunotherapy, 2011 Subcutaneous allergen-specific immunotherapy has long been used in allergic rhinitis and/or asthma and has been recognized to be efficacious. However, owing to the inconvenience of injection and the risk of serious side effects, alternative concepts ...
Nazan Cobanoglu
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Immunotherapy compliance: comparison of subcutaneous versus sublingual immunotherapy
International Forum of Allergy & Rhinology, 2015BackgroundPatient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively.MethodsA retrospective review of ...
Brittany A, Leader +5 more
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Systemic Reactions to Subcutaneous Allergen Immunotherapy
Immunology and Allergy Clinics of North America, 2011Subcutaneous allergen immunotherapy (SCIT) has been practiced for 100 years. Many trials have established the efficacy of SCIT in reducing symptoms of both seasonal allergic rhinitis and asthma due to aeroallergens. However, clinical benefits of SCIT are tempered by risks of injection-related systemic reactions and life-threatening anaphylaxis.
David I, Bernstein, Tolly, Epstein
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