Results 41 to 50 of about 312,772 (298)

Current role of immunotherapy in gastrointestinal cancers

, 2023
Immunotherapy has emerged as a groundbreaking treatment modality in the field of oncology, revolutionizing the management of various cancer types, including gastrointestinal cancers.
Ampah, Richard Kobina
core  

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Expert consensus on hypodermic care for allergen-specific immunotherapy

Allergy Medicine
Objective: To develop an expert consensus on subcutaneous injection for allergen-specific immunotherapy. Methods: Relevant domestic and international literature was reviewed, and nursing experts experienced in subcutaneous injection of allergen-specific ...
Wang Qing, Liu Jun, Zhi Fan, Wan Wenjin, Tian Fengying, Huo Xiaopeng, Zhou Wenhua, Yang Yongshi, Wang Tiantian, Sun Jinlyu   +9 more
doaj   +1 more source

Sublingual immunotherapy for the treatment of allergies

South African Family Practice, 2016
The treatment of allergies often involves pharmacological therapy and recommendations by healthcare workers that the allergen should be avoided. Allergen-specific immunotherapy has emerged as an alternative to effectively decrease the immunoglobulin (Ig)
Natalie Schellack, D. Engler
doaj   +1 more source

Identification of Robust Biomarkers for Early Predicting Efficacy of Subcutaneous Immunotherapy in Children With House Dust Mite-Induced Allergic Rhinitis by Multiple Cytokine Profiling

Frontiers in Immunology, 2022
BackgroundSubcutaneous immunotherapy (SCIT) is an effective treatment for children with allergic rhinitis (AR), but its efficacy fluctuates among patients. There are no reliable candidate biomarkers for monitoring and predicting the response to SCIT. The
Shaobing Xie, Shaobing Xie, Shaobing Xie, Ruohao Fan, Ruohao Fan, Ruohao Fan, Qingping Tang, Xiao Cai, Xiao Cai, Xiao Cai, Hua Zhang, Hua Zhang, Hua Zhang, Fengjun Wang, Fengjun Wang, Fengjun Wang, Shumin Xie, Shumin Xie, Shumin Xie, Kelei Gao, Kelei Gao, Kelei Gao, Junyi Zhang, Junyi Zhang, Junyi Zhang, Zhihai Xie, Zhihai Xie, Zhihai Xie, Weihong Jiang, Weihong Jiang, Weihong Jiang   +30 more
doaj   +1 more source

Tumor‐Targeted Hyaluronic Acid/Tannic Acid‐Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual‐Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment

Advanced Healthcare Materials, EarlyView.
A hyaluronic acid/tannic acid‐engineered Prussian blue oxygen nanogenerator loaded with IR780 is developed to enhance melanoma phototherapy. By integrating tumor targeting, oxygen self‐supply, and dual‐mode glutathione depletion, the nanoplatform effectively overcomes hypoxia and antioxidant defenses, potentiating synergistic photothermal/photodynamic ...
Chai‐How Hsu, I‐Ju Liu, Hsiang‐Yun Chih, Tsai‐Ching Hsu, Ju‐An Liang, Chia‐Wei Kuo, Bor‐Show Tzang, Wen‐Hsuan Chiang   +7 more
wiley   +1 more source

Local and systemic reactions to subcutaneous allergen immunotherapy

, 2016
Background: Local and especially systemic reactions are important problems in subcutaneous immunotherapy (SCIT).
Karaman, Sait, Erdem, Semiha Bahceci, Gunay, Ilker, Can, Demet, Sumer, Ozlem, ASİLSOY, SUNA, Karkiner, Canan Sule Unsal, Nacaroglu, Hikmet Tekin   +7 more
core   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, EarlyView.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Identification of Immune Cell Infiltration in Murine Pheochromocytoma during Combined Mannan-BAM, TLR Ligand, and Anti-CD40 Antibody-Based Immunotherapy

, 2021
Immunotherapy has become an essential component in cancer treatment. However, the majority of solid metastatic cancers, such as pheochromocytoma, are resistant to this approach.
Herui Wang, Katerina Hadrava Vanova, Boqun Zhu, Karel Pacak, Ondrej Uher, Claudia Palena, Rogelio Medina, Jan Zenka, Thanh-Truc Huynh, Lucas A. Horn, Veronika Caisova, Zhengping Zhuang, Jindrich Chmelar   +12 more
core   +1 more source