Results 101 to 110 of about 5,905,131 (283)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
research-subject-mapper 0.10.7
, 2016 Tools to generate patient-to-research subject mapping files based on inputs from REDCap ...
Radha Kandula +10 more
core +1 more source
npj Materials SustainabilityBioplastics promise lower-carbon alternatives to conventional plastics, yet their environmental performance remains contested. This review synthesizes evidence across three pillars: degradation pathways and micro/nanoplastic generation; chemical leaching
Vigneshwaran Shanmugam +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Matrimonial Failure in George Eliot’s Middlemarch: through the perspective of Social Exchange Theory
University of Chitral Journal of Linguistics and LiteratureThis paper aims at to analyze the causes of matrimonial failure in George Eliot’s Middlemarch among the central couples: Casaubon and Dorothea and Dr.
Naveed-ur-Rehman
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Role of Collection-Level Subject Metadata in Subject Access to Digital Collections in Aggregations [PDF]
, 2011 This paper presents a new area of research in library and information sciences - investigation into collection-level subject metadata that describes entire digital collections as integral wholes - and reports results of the multi-method exploratory study
Zavalina, Oksana
core